The following growth factors play a role in the development of uterine leiomyoma: EFR- epidermal growth factor, EFR-R- receptor of EFR, TGF- thrombocytic growth factor, TGFb- transforming growth factor beta, ILGF1 - insulin-like growth factor of the 1st type. These factors stimulate proliferation of cells, stroma and angiogenesis in the tumor. Mitotically active leiomyoma is characterized by a higher content of these growth factors vs ordinary and cellular leiomyomas. Treatment of uterine leiomyoma should be concentrated on removal of tumor cells from the body as leiomyomas especially its mitotically active variant produce growth factors which are able to stimulate tumor growth by the autocrine mechanism.
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