A morphological analysis of 50 cases of adenomyosis (AM) and 150 cases of AM combination with leiomyoma (LM) with regard to their morphofunctional and histotopographical interrelations was performed. The asynchronous character and mosaicism of estrogen/progesteron receptors expression in the gland epithelium and AM stromal cells of one patient was established immunohistochemically. This probably determines uneffective hormonal therapy of AM patients. A correlation of steroid hormone receptor expression in AM foci and in leiomyocytes of perifocal myometrium hyperplasia was also found. This indicates a common pathogenic mechanism of AM and LM. An increase of the size of the uterus depended on the degree of perifocal leiomyocyte hyperplasia with microscopical nodule formation in LM.
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