AI Article Synopsis
- The bacterial mutant strain B8/36 of Sphingomonas yanoikuyae was utilized to biotransform dictamnine and its 4-chlorofuroquinoline precursor, leading to the production of unique cis-dihydrodiol metabolites.
- These metabolites were created through a specific enzyme process involving biphenyl dioxygenase that facilitated the addition of hydroxyl groups.
- The resulting metabolites served as starting points in a chemoenzymatic method to synthesize various arene oxide and phenol intermediates, along with a range of derived furoquinoline alkaloids.
Article Abstract
Biotransformation of the parent furoquinoline alkaloid dictamnine and its 4-chlorofuroquinoline precursor, using the B8/36 bacterial mutant strain of Sphingomonas yanoikuyae, yielded, via biphenyl dioxygenase-catalysed dihydroxylation, the first isolable alkaloid cis-dihydrodiol metabolites; these metabolites were used in the chemoenzymatic synthesis of postulated arene oxide and phenol intermediates, and a range of derived furoquinoline alkaloids.
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| http://dx.doi.org/10.1039/b506944k | DOI Listing |
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