Objective: To determine the association between infection with Helicobacter pylori and dyspepsia.
Design: Cross sectional study of dyspeptic subjects and age and sex matched controls identified by a questionnaire survey of all inhabitants aged 20-69. (Endoscopy, histological examination, and microbiological examinations of biopsies from the gastric mucosa were performed blind.)
Setting: Population based survey in Sørreisa, Norway.
Subjects: All 782 dyspeptic subjects (excluding those with a previous history of peptic ulcer, gall stones or kidney stones, and coronary heart disease) and controls were offered an endoscopy, of whom 309 dyspeptic subjects and 310 controls attended.
Main Outcome Measures: Prevalences of endoscopic and histological diagnoses and of cultures positive for H pylori.
Results: A high prevalence of positive cultures, increasing with age, was found in both dyspeptic subjects (48%) and non-dyspeptic controls (36%) (p = 0.004). Positive cultures in both dyspeptic subjects and controls were strongly associated with histological gastritis (70%, 95% confidence interval 65.5 to 85.3; 60%, 52.7 to 67.7, respectively) and peptic ulcer (92%, 61.5 to 99.8; 64.1, 9.4 to 99.2, respectively). Only 3% of subjects with a histologically non-inflamed gastric mucosa had this infection (dyspeptic subjects 2%, 0.2 to 7.0; controls 4%; 1.2 to 8.8).
Conclusions: The relation between dyspeptic symptoms and H pylori is dubious; H pylori seems to have a pathogenetic role in gastritis and may be a contributing factor but not a cause of peptic ulcer.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1881886 | PMC |
| http://dx.doi.org/10.1136/bmj.304.6837.1276 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Randomized clinical trial: the effects of mirtazapine in functional dyspepsia patients.
Therap Adv Gastroenterol
January 2025
Center of Health Management, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan, Shandong 250012, China.
Background: Functional dyspepsia (FD) is one of the most common gastrointestinal disorders worldwide. Currently, anti-gastric drugs, gastric acid inhibitors, prokinetic drugs, and mucosal protective drugs are widely used in FD patients, however, only a small proportion of patients benefit from these drugs. Studies reported mirtazapine may improve symptoms of FD patients but the efficacy and safety of mirtazapine in the treatment of FD is unclear.
View Article and Find Full Text PDFHelicobacter pylori Infection: Prevalence, Risk Factors, and Treatment Efficacy in Symptomatic Patients in Zakho City, Kurdistan Region, Iraq.
Cureus
November 2024
Department of Biology, College of Science, University of Zakho, Zakho, IRQ.
Article Synopsis
- The study focused on the prevalence of a common bacterium among 100 dyspeptic patients in Zakho City, Iraq, finding an infection rate of 50%.
- Significant associations were found between the bacterium and factors like increasing age, low hemoglobin levels, and educational level, while no major differences were seen in gender, smoking, or other lifestyle factors.
- Additionally, nearly half of the patients did not respond to standard antibiotic treatment, indicating a potential antibiotic resistance issue and highlighting the need for customized treatment strategies.
Comparison of hematologic parameters, serum electrolytes, and lipid profiles among dyspeptic patients with and without Helicobacter pylori infection attending Jimma Medical Center, Jimma, South West Ethiopia.
PLoS One
November 2024
Department of Biochemistry, School of Biomedical Sciences, Jimma University, Jimma, Ethiopia.
Article Synopsis
- Helicobacter pylori (H.pylori) infection is highly prevalent in Ethiopia and is linked to cardiovascular disease and anemia, but there is limited data on its associated risk factors such as blood parameters and lipid profiles.
- A study involving 108 dyspeptic patients at Jimma Medical Center analyzed blood samples to evaluate the effects of H.pylori infection using advanced medical equipment and statistical methods.
- Results indicated that H.pylori infected patients had lower red blood cell counts and sodium levels, alongside higher cholesterol and low-density lipoprotein levels, suggesting significant health impacts from the infection.
Background A growing number of studies suggest that anemia caused by () infection is prevalent in developing countries. A combination of eradication and iron supplementation may be effective in treating iron deficiency anemia (IDA) caused by infection. The aim of this study is to assess the prevalence, risk factors, and treatment outcomes of anemia in Vietnamese school-age children infected with H.
View Article and Find Full Text PDFHelicobacter pylori cagA/vacAs1-m1 strain is associated with high risk of fibrosis in metabolic-dysfunction-associated steatotic liver disease.
Ann Hepatol
October 2024
Laboratorio de Biotecnología Molecular (BIOTECMOL), Instituto de Biotecnología de Misiones "Dra. María Ebbe Reca" (InBioMis), Facultad de Ciencias Exactas Químicas y Naturales, Universidad Nacional de Misiones, Misiones, Argentina; CONICET, Buenos Aires, Argentina. Electronic address:
Article Synopsis
- The study investigates the link between H. pylori virulence genes and liver damage markers in patients with metabolic dysfunction associated steatotic liver disease (MASLD).
- A total of 362 dyspeptic patients were analyzed, finding that 42% had MASLD and 45% were H. pylori-positive, with H. pylori positivity linked to higher liver injury indicators.
- Specifically, carriers of the cagA/vacA-s1/m1 allele displayed a higher risk for significant liver fibrosis compared to those without this allelic combination, indicating a need for further research in this area.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!