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Sister chromatid cohesion through the lens of biochemical experiments.
Curr Opin Cell Biol
January 2025
Department of Chromosome Science, National Institute of Genetics, Mishima, 411-8540, Japan; Department of Genetics, Graduate University for Advanced Studies (SOKENDAI), Mishima, 411-8540, Japan. Electronic address:
Faithful chromosome segregation in eukaryotes relies on physical cohesion between newly duplicated sister chromatids. Cohesin is a ring-shaped ATPase assembly that mediates sister chromatid cohesion through its ability to topologically entrap DNA. Cohesin, assisted by several regulatory proteins, binds to DNA prior to DNA replication and then holds two sister DNAs together when it encounters the replication machinery.
View Article and Find Full Text PDFDispersive heterodyne cavity ring-down spectroscopy exploiting eigenmode frequencies for high-fidelity measurements.
Sci Adv
January 2025
Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Toruń, Grudziadzka 5, 87-100 Torun, Poland.
Measuring low light absorption with combined uncertainty <1 per mil (‰) is crucial for many applications. Popular cavity ring-down spectroscopy can provide ultrahigh precision, below 0.01‰, but its accuracy is often worse than 5‰ due to inaccuracies in light intensity measurements.
View Article and Find Full Text PDFPrecise Measurement of the e^{+}e^{-}→D_{s}^{+}D_{s}^{-} Cross Section at Center-of-Mass Energies from Threshold to 4.95 GeV.
Phys Rev Lett
December 2024
State Key Laboratory of Particle Detection and Electronics, Beijing 100049, Hefei 230026, People's Republic of China.
Using the e^{+}e^{-} collision data collected with the BESIII detector operating at the BEPCII collider, at center-of-mass energies from the threshold to 4.95 GeV, we present precise measurements of the cross section for the process e^{+}e^{-}→D_{s}^{+}D_{s}^{-} using a single-tag method. The resulting cross section line shape exhibits several new structures, thereby offering an input for a future coupled-channel analysis and model tests, which are critical to understand vector charmonium-like states with masses between 4 and 5 GeV.
View Article and Find Full Text PDFDesign, synthesis, anti-inflammatory evaluation, and molecular docking studies of novel quinazoline-4(3)-one-2-carbothioamide derivatives.
RSC Adv
January 2025
Institute of Chemistry, Vietnam Academy of Science and Technology Hanoi Vietnam
In this paper, a series of novel quinazoline-4(3)-one-2-carbothioamide derivatives (8a-p) were designed and synthesized the Wilgerodt-Kindler reaction between 2-methylquinazoline-4-one 10 and amines using S/DMSO as the oxidizing system. Their characteristics were confirmed by IR, NMR, HRMS spectra, and their melting point. These novel derivatives (8a-p) were evaluated for their anti-inflammatory activity by inhibiting NO production in lipopolysaccharide (LPS)-activated RAW 264.
View Article and Find Full Text PDFIn this paper, the focusing and tight-focusing properties of radially polarized (RP) Bessel-Gaussian (BG) rotationally-symmetric power-exponent-phase vortex beam (RPVBs) were investigated theoretically and experimentally. Based on the theory of vector beam, the propagation and tight-focusing models were derived to reveal the focusing and tight-focusing properties of the RP-BG-RPVBs by numerical simulation. Then, the experimental setup was established to validate that the RP-BG-RPVBs presented the fan-shaped and polycyclic intensity distribution, which possessed the features of RP beams, BG beams, and RPVBs, similarly.
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