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Factors Influencing Nerinetide Effect on Infarct Volume in Patients Without Alteplase in the Randomized ESCAPE-NA1 Trial.
Stroke
January 2025
Department of Diagnostic Imaging (J.M.O., M.G., B.K.M., M.A.A., A.M.D., M.J., M.D.H.), University of Calgary, Alberta, Canada.
Background: In the ESCAPE-NA1 trial (Efficacy and Safety of Nerinetide for the Treatment of Acute Ischemic Stroke), treatment with nerinetide was associated with a smaller infarct volume among patients who did not receive intravenous alteplase. We assessed the effect of nerinetide on the surrogate imaging outcome of final infarct volume in patients who did not receive intravenous alteplase and explored predictors of outcome and modifiers of nerinetide's effect on infarct volume.
Methods: ESCAPE-NA1 was a multicenter, randomized trial in which patients with acute stroke with a baseline Alberta Stroke Program Early CT Score >4, undergoing endovascular thrombectomy, were randomized to receive intravenous nerinetide or placebo.
Chronic total occlusion of renal artery in symptomatic young patient with resistant hypertension: is a revascularization necessary or redundant?
J Hypertens
January 2025
Department of Photomedicine and Physical Chemistry, Medical College of The Rzeszów University, Rzeszów, Poland.
Article Synopsis
- Renal artery stenosis (RAS) is a condition where the renal artery is narrowed by 60% or more, most commonly due to atherosclerotic plaques, affecting 5-10% of the population; rare causes include fibromuscular dysplasia and vasculitis.
- The standard diagnostic method for RAS is digital subtraction angiography (DSA), but other imaging techniques like Doppler ultrasonography and CT angiography are also important.
- Treatment typically involves percutaneous transluminal angioplasty (PTA), and a case study highlights a 19-year-old patient who benefitted from using a paclitaxel-coated balloon to restore renal artery function and reduce hypertension.
Neuroprotective effect of Sigma-2 modulator CT2074 in a mouse model of ocular hypertension.
Exp Eye Res
December 2024
Department of Pharmaceutical Sciences, North Texas Eye Research Institute, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX, 76107, USA. Electronic address:
Article Synopsis
- Ocular neurodegenerative diseases like glaucoma are major causes of blindness, and current treatments do not effectively prevent damage to the retina and optic nerve.
- Research highlights sigma-2 receptors as a promising target for neuroprotective therapies, with this study focusing on a drug called CT2074 in a mouse model of glaucoma.
- Results demonstrated that mice treated with CT2074 had significantly more retinal ganglion cells compared to those that received no treatment, suggesting that CT2074 may help protect against retinal damage from increased intraocular pressure.
Phase-Resolved Functional Lung MRI for Pulmonary Ventilation and Perfusion (V/Q) Assessment.
J Vis Exp
August 2024
Institute for Diagnostic and Interventional Radiology, Hannover Medical School; Member of the German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH).
Fourier decomposition is a contrast agent-free 1H MRI method for lung perfusion (Q) and ventilation (V) assessment. After image registration, the time series of each voxel is analyzed with regard to the cardiac and breathing frequency components. Using a standard 2D spoiled gradient-echo sequence with a temporal resolution of ~300 ms, an image-sorting algorithm was developed to produce phase-resolved functional lung imaging (PREFUL) with an increased temporal resolution.
View Article and Find Full Text PDFShort term outcome of neonatal venous thromboembolism in anticoagulated versus observed patients.
Thromb Res
September 2024
Pediatric Hematology/Oncology, OU Children's Hospital, Oklahoma City, OK, United States of America.
Background: Advancements in the medical field and increased survival of premature infants have led to a rise of venous thromboembolism (VTE) in neonates. Neonatal hemostasis exists in a delicate balance with a propensity towards pro-coagulation. Current recommendations include careful observation, therapeutic anti-coagulation and in some cases thrombolysis.
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