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| http://dx.doi.org/10.1111/j.1535-7597.2004.04515.x | DOI Listing |
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Global modified Delphi consensus on diagnosis, phenotypes, and treatment of SCN8A-related epilepsy and/or neurodevelopmental disorders.
Epilepsia
August 2024
Jane and John Justin Institute for Mind Health, Neurosciences Center, Cook Children's Medical Center, Fort Worth, Texas, USA.
Objective: We aimed to develop consensus for diagnosis/management of SCN8A-related disorders. Utilizing a modified Delphi process, a global cohort of experienced clinicians and caregivers provided input on diagnosis, phenotypes, treatment, and management of SCN8A-related disorders.
Methods: A Core Panel (13 clinicians, one researcher, six caregivers), divided into three subgroups (diagnosis/phenotypes, treatment, comorbidities/prognosis), performed a literature review and developed questions for the modified Delphi process.
Management of epilepsy with eyelid myoclonia: Results of an international expert consensus panel.
Epilepsia
September 2023
Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.
Objective: There are limited data about the treatment and management of epilepsy with eyelid myoclonia (EEM). The objective of this study was to determine areas of consensus among an international panel of experts for the management of EEM (formerly known as Jeavons syndrome).
Methods: An international steering committee was convened of physicians and patients/caregivers with expertise in EEM.
An Italian consensus on the management of Lennox-Gastaut syndrome.
Seizure
October 2022
Paediatric Neurology and Muscular Disease Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy. Electronic address:
Purpose: Although international guidelines exist, the clinical heterogeneity of Lennox-Gastaut syndrome (LGS) and the increasing availability of new and repurposed drugs (e.g., fenfluramine and cannabidiol) requires a practical guide to patient management in the clinical context.
View Article and Find Full Text PDFNeurodevelopmental outcomes in children exposed prenatally to levetiracetam.
Ther Adv Drug Saf
March 2022
Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, P.O Box 84428, Riyadh 11671, Saudi Arabia.
Unlabelled: Some old antiseizure medications (ASMs) pose teratogenic risks, including major congenital malformations and neurodevelopmental delay. Therefore, the use of new ASMs in pregnancy is increasing, particularly lamotrigine and levetiracetam. This is likely due to evidence of low risk of anatomical teratogenicity for both lamotrigine and levetiracetam.
View Article and Find Full Text PDFRapid and direct concentration range judgment of lamotrigine in plasma by the multi test lines with different detection limits on the same lateral flow strip.
Anal Chim Acta
February 2022
Engineering Research Center of Bio-process, MOE, School of Food and Biological Engineering, Intelligent Manufacturing Institute, Hefei University of Technology, Hefei, 230009, China. Electronic address:
Continuous and interval monitoring of target drug concentration is of great importance for the effective and controllable therapy of diseases. In this research, the colloidal gold labeled lateral flow strip (LFS) is utilized for rapid and direct judgement of lamotrigine (LTG) concentration range, a specific medicine for epilepsy with the effective therapeutic concentration from 2.5 to 15 μg/mL in serum (corresponding to 25-150 ng/mL after 100-time dilution).
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