Non-bacterial thrombotic endocarditis is a recognised complication of malignancy (occurring in 0.3-9.3% of patients in autopsy series), and is most commonly associated with lung cancer. We describe a fatal case of non-bacterial thrombotic endocarditis associated with stage IIIB adenocarcinoma of the lung in which the transoesophageal echocardiogram was negative. Recommendations for management of such cases are given.
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BMJ Case Rep
January 2025
Cardiology, East Cheshire NHS Trust, Macclesfield, UK.
Non-bacterial thrombotic endocarditis (NBTE) is characterised by sterile vegetations on heart valves and often emerges in hypercoagulable states like malignancy. It is frequently underdiagnosed and only comes to light during postmortem examination. Early diagnosis and treatment with anticoagulation can help lower mortality.
View Article and Find Full Text PDFIntern Med
December 2024
Division of Cardiovascular Surgery, Oita Prefectural Hospital, Japan.
Non-bacterial thrombotic endocarditis (NBTE) causes myocardial and cerebral infarctions and is associated with advanced stages of malignancy. However, only a few cases of myocardial and cerebral infarctions have been reported in the same patient. We herein report a 47-year-old woman with advanced uterine and ovarian cancer who experienced acute myocardial infarction (MI) after receiving chemotherapeutic intervention for the cancer and hemorrhagic cerebral infarction 1 month after admission for acute MI, attributable to NBTE of the aortic valve.
View Article and Find Full Text PDFJ Stroke Cerebrovasc Dis
February 2025
Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA. Electronic address:
Background: Very limited data indicate that patients with stroke from cancer-associated NBTE (Ca-NBTE) exhibit a characteristic pattern of widely distributed ischemic lesions of varying sizes.
Methods: An electronic search of Mayo Clinic records (03/31/2002-06/30/2022) with ensuing manual review of brain magnetic resonance imaging (MRI) was performed to identify topographic characteristics of stroke from Ca-NBTE.
Results: In 112 patients with Ca-NBTE, 92 (82.
Eur Heart J
January 2025
Department of Cardiology, University of Texas Health Sciences Center, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.
Non-bacterial thrombotic endocarditis (NBTE), formerly recognized as marantic endocarditis, represents a rare cardiovascular pathology intricately linked with hypercoagulable states, notably malignancy and autoimmune disorders. Characterized by the development of sterile vegetations comprised of fibrin and platelets on cardiac valves, NBTE poses a diagnostic challenge due to its resemblance to infective endocarditis. Therapeutic endeavours primarily revolve around addressing the underlying aetiology and instituting anticoagulant regimens to forestall embolic events, with surgical intervention seldom warranted.
View Article and Find Full Text PDFGen Thorac Cardiovasc Surg Cases
August 2024
Department of Cardiovascular Surgery, NHO Takasaki General Medical Center, Gunma, Japan.
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