AI Article Synopsis
- The study investigated early erythroid precursors in human bone marrow to understand "microproerythroblasts," small versions of proerythroblasts.
- The researchers used a silver reaction technique to analyze nucleolar organizer regions (AgNORs) and employed light microscopy for RNA staining.
- Results showed no significant differences in nucleolar density and basophilic cytoplasm between large proerythroblasts and "microproerythroblasts," though "microproerythroblasts" had slightly fewer AgNORs than their larger counterparts.
Article Abstract
Early erythroid precursors were studied in human bone marrow smears to provide more information on small proerythroblasts--"microproerythroblasts"--using a silver reaction to demonstrate silver stained nucleolar organizer regions (AgNORs) and light microscopic densitometry of large irregularly shaped nucleoli and cytoplasm stained for RNA. No significant differences were found for the density of such nucleoli and basophilic cytoplasm between characteristic large proerythroblasts with a nuclear diameter larger that 9 microm (K2 and K1 erythroblasts) and small proerythroblasts--"microproerythroblasts" representing a subpopulation of K1/2 erythroblasts (early basophilic erythroblasts), which are characterized by a smaller nuclear diameter. In addition, large irregularly shaped nucleoli of "microproerythroblasts" possessed numerous silver stained particles representing AgNORs similar to those of large proerythroblasts. The number of AgNORs in "microproerythroblasts" was slightly, but significantly, smaller than that in large characteristic proerythroblasts.
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| http://dx.doi.org/10.1016/j.acthis.2005.06.004 | DOI Listing |
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