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Outcomes of SWI/SNF complex-deficient sinonasal carcinomas in a Southeast Asian cohort.
Head Neck
January 2025
Department of Otolaryngology - Head & Neck Surgery, National University Hospital, Singapore, Singapore.
Background: SWI/SNF complex-deficient sinonasal carcinomas are rare, genetically distinct, and aggressive entities.
Methods: SMARCB1 and SMARCA4 immunohistochemistry was retrospectively performed on a cohort of undifferentiated, poorly differentiated, and poorly defined sinonasal carcinomas. Survival outcomes were compared between SMARCB1/SMARCA4 (SWI/SNF complex)-deficient and -retained groups.
Risk of recurrence after neoadjuvant chemotherapy and transoral robotic surgery in patients with oropharynx cancer that avoid adjuvant radiation.
Cancer Med
April 2024
Center for Immuno-Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Background: De-escalation strategies for newly-diagnosed p16-positive oropharyngeal squamous cell carcinoma (p16+ OPSCC), aim to reduce treatment-related morbidity without compromising disease control. One strategy is neoadjuvant cisplatin and docetaxel chemotherapy (NAC + S) before transoral robotic surgery, with pathology-based risk-adapted adjuvant treatment.
Methods: We examined the recurrence-free survival (RFS) for patients who received NAC + S.
Asleep triple-modality motor mapping for perirolandic gliomas: an update on outcomes.
J Neurosurg
April 2024
1Department of Neurological Surgery, University of California, San Francisco, California; and.
Objective: Maximal safe resection of gliomas near motor pathways is facilitated by intraoperative mapping. Here, the authors review their results with triple-modality asleep motor mapping with motor evoked potentials and bipolar and monopolar stimulation for cortical and subcortical mapping during glioma surgery in an expanded cohort.
Methods: This was a retrospective analysis of patients who underwent resection of a perirolandic glioma near motor pathways.
Triple modality image reconstruction of PET data using SPECT, PET, CT information increases lesion uptake in images of patients treated with radioembolization with [Formula: see text] micro-spheres.
EJNMMI Phys
May 2023
Nuclear Medicine Institute, University College London, London, UK.
Purpose: Nuclear medicine imaging modalities like computed tomography (CT), single photon emission CT (SPECT) and positron emission tomography (PET) are employed in the field of theranostics to estimate and plan the dose delivered to tumors and the surrounding tissues and to monitor the effect of the therapy. However, therapeutic radionuclides often provide poor images, which translate to inaccurate treatment planning and inadequate monitoring images. Multimodality information can be exploited in the reconstruction to enhance image quality.
View Article and Find Full Text PDFEffects of multimodal pain management strategies on acute physiological and behavioral response to cautery disbudding in neonatal goat kids.
J Dairy Sci
April 2023
Department of Life Sciences, University of Lincoln, Lincoln LN6 7DL, UK.
Dairy goat kids are commonly disbudded in the United States without pain relief. Our objective was to identify an efficient pain management strategy by monitoring changes in plasma biomarkers and behavior of disbudded goat kids. A total of 42 kids (5-18 d old at the time of disbudding) were randomly allocated to 1 of 7 treatments (n = 6/treatment): sham treatment; 0.
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