AI Article Synopsis
- The HIV-1 surface Env protein is linked to the development of HIV-1-associated dementia (HAD).
- Analysis of 27 infected subjects showed that the diversity of the env gene varies significantly between blood and cerebral spinal fluid (CSF).
- In patients with HAD, there are more unique env variants in the CSF, suggesting that these variants may promote replication in the brain, contributing to the disease's development.
Article Abstract
The human immunodeficiency virus type 1 (HIV-1) surface Env protein has been implicated in the development of HIV-1-associated dementia (HAD). HIV-1 env diversity was analyzed by heteroduplex tracking assay in 27 infected subjects with various neurological statuses. env compartmentalization between the blood and cerebral spinal fluid (CSF) was apparent with all neurological categories. However, in subjects with HAD, significantly more CSF virus was represented by CNS-unique env variants. Variants specialized for replication in the CNS may play a larger role in the development of HAD. Alternatively, HAD may be associated with a more pronounced state of immunosuppression that permits more extensive replication and independent evolution within the CNS compartment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182623 | PMC |
| http://dx.doi.org/10.1128/JVI.79.16.10830-10834.2005 | DOI Listing |
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