AI Article Synopsis
- The study aims to investigate the link between different sources of drinking water and the risk of colorectal cancer (CRC) among residents in China, addressing a gap in direct prospective cohort studies.
- A total of 64,115 residents were followed for about a decade, with various drinking water sources categorized and analyzed for their association with CRC using statistical methods to control for confounding factors.
- Results indicated that well water significantly increased the risk of CRC, particularly rectal cancer, compared to municipal water, suggesting that long-term consumption of well water may pose health risks.
Article Abstract
Background: The pollution of drinking water, e.g. from rivers and pools, has long been recognized to be associated with an increased risk for colorectal cancer (CRC), but there are few direct prospective cohort studies related to person-years on the relative risks of different sources of drinking water for CRC, hence the reason for our study.
Methods: Based on a screening for CRC among residents aged 30 years and over in Jiashan County, Zhejiang Province, China, a total of 64,115 residents were classified into five cohorts by their source of drinking water and followed-up from 1st May 1990 to 1st January 2001. Person-years was calculated for every cohort member and Poisson regression was used to control potential confounding variables including demographic variables and smoking history, and to attain crude and adjusted relative risks based on person-years.
Results: A trend was seen toward increasing incidence rates for CRC from the drinking water sources of municipal, river, ditch, mixed water to well in turn as shown by relative risk rates of 29.61, 32.67, 33.45, 40.87 and 58.67 per 100,000 inhabitants. Only the role in risk of well water was significantly different from municipal water (P < 0.05). After the confounding variables were adjusted, the significant risk from well water could be seen for colon cancer, rectal cancer as well as CRC. The relative risks were 1.741 [95% confidence interval (CI) 1.001-3.029], 2.228 (95% CI 1.432-3.466) and 2.022 (95% CI 1.432-2.854), respectively.
Conclusion: Drinking well water over a long period was identified as playing a role in the risk for CRC, especially for rectal cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/eurpub/cki027 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Lactiplantibacillus plantarum P101 Alleviates Liver Toxicity of Combined Microplastics and Di-(2-Ethylhexyl) Phthalate via Regulating Gut Microbiota.
Probiotics Antimicrob Proteins
January 2025
State Key Laboratory of Food Science and Resources, Nanchang University, 235 Nanjing East Road, Nanchang, 330047, China.
Microplastics (MPs) and Di-(2-ethylhexyl) phthalate (DEHP) as emerging contaminants, have caused increasing concern due to their co-exposure risks and toxicities to humans. Lactic acid bacteria have been demonstrated to play a significant role in the mitigation of organismal damage. Probiotic intervention is widely recognized as a safe and healthy therapeutic strategy for targeting the mitigation of organic damage.
View Article and Find Full Text PDFSpatio-temporal variation of microbial indicators of river water and treatment efficiencies of drinking water treatment plants along the upper Mahaweli River segment of Sri Lanka.
Environ Pollut
January 2025
University of Peradeniya, Peradeniya 20400, Sri Lanka. Electronic address:
The microbial pollution status of river surface water is important to ensure a river-based quality drinking water supply for the public. The present study aimed to investigate bacterial contamination status in the upper Mahaweli River, the main drinking water supplier to the hill country of Sri Lanka. Both the raw surface water and treated water, taken at 14 drinking water treatment plants (DWTPs) along the river segment of 60 km between Kotmale and Victoria reservoirs, were tested for total bacterial counts (TBC), total coliform counts (TCC) and faecal coliform counts (FCC).
View Article and Find Full Text PDFGold nanoparticles supported onto zwitterionic polymer capillary monoliths meant for efficient enrichment of microcystins in water.
Talanta
December 2024
Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350116, China; International (HongKong Macao and Taiwan) Joint Laboratory on food safety and environmental analysis, Fuzhou, 350116, Fuzhou University, China; Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety, Fuzhou, 350116, China. Electronic address:
The release of microcystin (MCs) in aquatic ecosystems poses a substantial risk to the safety of irrigation and drinking water. In view of the challenges associated with monitoring MCs in water bodies, given their low concentration levels (μg/L to ng/L) and the presence of diverse matrix interferences, there is an urgent need to develop an efficient, cost-effective and selective enrichment technique for MCs prior to its quantification. In this work, a gold nanoparticles (AuNPs)-functionalized zwitterionic polymer monolith was described and further applied for the affinity enrichment of MCs.
View Article and Find Full Text PDFSpatial assessment of drinking water flavor in China: Revealing regional disparities and underlying drivers.
Water Res
December 2024
The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou 324000, China.
Drinking water flavor, a critical water quality metric, exhibits substantial regional variations across China, influenced by local geology and chemistry. Despite growing consumer concerns about water flavor, a spatial assessment of the determinants of water flavor in China has been notably lacking. This study bridges this gap by conducting a spatially comprehensive analysis of 78 tap water samples throughout China.
View Article and Find Full Text PDFDifferential insights into the distribution characteristics of bacterial communities and their response to typical pollutants in the sediment and soil of large drinking water reservoir.
J Environ Manage
January 2025
School of Resources and Environmental Engineering, Hefei University of Technology, Hefei, 230009, China. Electronic address:
In this study, a large drinking water reservoir (Fengshuba Reservoir) was chosen as a representative case, and the bacterial communities in the sediments and soils of Water-level fluctuating zone (WLFZ) as well as their responses to heavy metals (HMs) and polycyclic aromatic hydrocarbons (PAHs) were systematically investigated. The results indicated that the abundance and diversity of the bacterial community obviously changed with seasonal hydrological variations in sediments, and the absolute abundance and composition of bacteria community differed significantly between the sediment phase and soil phase. Bacteria with the ability to degrade pollutants rapidly proliferate and gain ascendancy in the soil phase, with Burkholderia-Caballeronia-Paraburkholderia (B-C-P) and Bradyrhizobium forming the core of the largest community.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!