AI Article Synopsis
- In experimental decerebration, mammals have their cerebral cortex and thalamus inactivated using general anesthesia, resulting in no pain sensation or consciousness after the anesthesia wears off.
- The classification of decerebrate animals under USDA pain categories is debated, as it's unclear if they should be in category D (where pain is addressed by drugs) or E (where pain is unrelieved).
- The authors advocate for placing decerebrate animals in category D and offer insights on decerebration processes and recommendations for animal care committees evaluating such procedures.
Article Abstract
In experimental decerebration of mammals, the cerebral cortex and thalamus are surgically or otherwise inactivated under traditional (pharmacologic) general anesthesia. Once the effects of the pharmacologic anesthesia have dissipated, the animal remains alive, but there is neither pain sensation nor consciousness. Because the Animal Welfare Act and its regulations recognize drugs as the only means to alleviate pain, it is unclear whether a decerebrate animal should be placed in U.S. Department of Agriculture (USDA) pain and distress category D (pain or distress alleviated by drugs) or E (unalleviated pain or distress). We present a rationale for including decerebrate animals in USDA category D. We also provide a general review of decerebration and suggestions for institutional animal care and use committees having to evaluate decerebration protocols.
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