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| http://dx.doi.org/10.1370/afm.360 | DOI Listing |
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The GeoTox Package: open-source software for connecting spatiotemporal exposure to individual and population-level risk.
Hum Genomics
January 2025
Predictive Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, 530 Davis Dr, Durham, NC, 27713, USA.
Background: Comprehensive environmental risk characterization, encompassing physical, chemical, social, ecological, and lifestyle stressors, necessitates innovative approaches to handle the escalating complexity. This is especially true when considering individual and population-level diversity, where the myriad combinations of real-world exposures magnify the combinatoric challenges. The GeoTox framework offers a tractable solution by integrating geospatial exposure data from source-to-outcome in a series of modular, interconnected steps.
View Article and Find Full Text PDFCemented Modular Bipolar Hemiarthroplasty for Displaced Femoral Neck Fractures in the Elderly.
Cureus
November 2024
Trauma and Orthopedic Surgery, Services Hospital Lahore, Lahore, PAK.
Objective To determine the outcomes of cemented modular bipolar hemiarthroplasty for displaced femoral neck fractures in the elderly. Methodology This prospective study involved 102 elderly patients with clinically and radiologically confirmed displaced femoral neck fractures and was conducted in the Department of Trauma and Orthopedic Surgery, Unit-1, Services Hospital, Lahore. Cemented bipolar hemiarthroplasty was performed on all patients.
View Article and Find Full Text PDFArchitectural dissection of adhesive bacterial cell surface appendages from a "molecular machines" viewpoint.
J Bacteriol
December 2024
Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
The ability of bacteria to interact with and respond to their environment is crucial to their lifestyle and survival. Bacterial cells routinely need to engage with extracellular target molecules, in locations spatially separated from their cell surface. Engagement with distant targets allows bacteria to adhere to abiotic surfaces and host cells, sense harmful or friendly molecules in their vicinity, as well as establish symbiotic interactions with neighboring cells in multicellular communities such as biofilms.
View Article and Find Full Text PDFThe GeoTox Package: Open-source software for connecting spatiotemporal exposure to individual and population-level risk.
medRxiv
November 2024
Predictive Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, 530 Davis Dr, Durham, 27713, NC, USA.
Background: Comprehensive environmental risk characterization, encompassing physical, chemical, social, ecological, and lifestyle stressors, necessitates innovative approaches to handle the escalating complexity. This is especially true when considering individual and population-level diversity, where the myriad combinations of real-world exposures magnify the combinatoric challenges. The GeoTox framework offers a tractable solution by integrating geospatial exposure data from source-to-outcome in a series of modular, interconnected steps.
View Article and Find Full Text PDFDistributed associations among white matter hyperintensities and structural brain networks with fluid cognition in healthy aging.
Cogn Affect Behav Neurosci
December 2024
Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, USA.
White matter hyperintensities (WMHs) are associated with age-related cognitive impairment and increased risk of Alzheimer's disease. However, the manner by which WMHs contribute to cognitive impairment is unclear. Using a combination of predictive modeling and network neuroscience, we investigated the relationship between structural white matter connectivity and age, fluid cognition, and WMHs in 68 healthy adults (18-78 years).
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