AI Article Synopsis
- Long-term use of hydroxyurea (HU) therapy is linked to various skin side effects, including a reported first case of neuroendocrine carcinoma associated with the drug.
- The patient had been treated with HU for thrombocythemia for two years, but the treatment was stopped due to a skin eruption resembling dermatomyositis.
- Years later, she developed multiple keratotic lesions and ultimately a Merkel cell carcinoma on her finger, suggesting a potential link to HU while also acknowledging that it could be a coincidence.
Article Abstract
Many cutaneous side-effects of long term use of hydroxyurea (HU) therapy are well known. We report the first case, to our knowledge, of a neuroendocrine carcinoma located on the finger associated with other cutaneous changes due to this drug. Our patient received HU for two years for an thrombocytemia. This treatment was stopped because of a dermatomyositis-like eruption. Two years later, she developed multiple keratotic lesions, and eight years later, an Merkel cell carcinoma on the third left finger with metastasic evolution. This case suggests HU could be a cofactor of this neuroendocrine carcinoma but a simple coincidence could not be excluded.
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