An efficient synthesis of gougerotin and related analogues using solid- and solution-phase methodology.

Org Lett

Ibis Therapeutics, a Division of Isis Pharmaceuticals, Inc., 1896 Rutherford Avenue, Carlsbad, CA 52008, USA.

Published: August 2005

The first solid-phase synthesis of the natural product gougerotin has been accomplished. The synthetic route is versatile and allows for diversification at position C-4 of the heterocycle, C-6' of the sugar ring, and both residues of the peptidic moiety at N-4' in a parallel fashion. [structure: see text]

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http://dx.doi.org/10.1021/ol0507322DOI Listing

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