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The Challenge of Bacterial Strain Identification: Serovars Australis in a Dog and Long-Term Clinical Follow-Up.
Trop Med Infect Dis
November 2024
Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell'Università 10, 35020 Legnaro, Italy.
Leptospirosis is a widespread disease throughout the world, presenting in severe clinical forms in dogs. The pathogenicity of the different serovars in field infections is not fully documented, and clinical diagnosis is often limited to a combination of serological tests and molecular analyses. The latter, although a fundamental tool, cannot identify the infecting strain without further analysis.
View Article and Find Full Text PDFSeroepidemiology of human leptospirosis in the Dominican Republic: A multistage cluster survey, 2021.
PLoS Negl Trop Dis
December 2024
University of Queensland Centre of Clinical Research (UQCCR), University of Queensland, Brisbane, Australia.
Little is known about the epidemiology of leptospirosis in the Dominican Republic, the second most populous country in the Caribbean. We report on findings from a multi-stage household survey across two regions in the country that reveals a previously under-estimated burden of human Leptospira infection. Our findings, based on the reference-standard microscopic agglutination test, indicate a complex picture of serogroup diversity, spatial heterogeneity in infection and risk, and a marked discrepancy between reported cases and serologically estimated infections.
View Article and Find Full Text PDFLeptospirosis manifested with severe pulmonary hemorrhagic syndrome successfully treated with veno-venous extracorporeal membrane oxygenation: A case report and literature review.
Medicine (Baltimore)
December 2024
Department of Critical Care Medicine, Fuyang Infectious Disease Clinical College of Anhui Medical University, Fuyang, Anhui Province, China.
Rationale: The mortality rate associated with pulmonary hemorrhage induced by leptospirosis is notably high. Available treatment modalities are limited, and their efficacy has not been fully demonstrated. Here, we present the case report of a patient with leptospirosis-induced pulmonary hemorrhagic syndrome.
View Article and Find Full Text PDFTriple Co-infection With Salmonella typhi, Leptospira, and Campylobacter coli in a Patient From Guayaquil, Ecuador: Clinical and Diagnostic Challenges.
Cureus
November 2024
Medicine, University of Guayaquil, Guayaquil, ECU.
This case report describes the unusual presentation of a 32-year-old male from Guayaquil, Ecuador, who was diagnosed with a rare triple infection caused by , , and . The patient presented with persistent high fever, severe gastrointestinal symptoms, abdominal pain, and jaundice, following the consumption of street food in a resource-limited area. Important clinical findings included hepatosplenomegaly and elevated liver enzymes, which initially complicated the differential diagnosis.
View Article and Find Full Text PDFPredicting Leptospirosis Using Baseline Laboratory Tests and Geospatial Mapping of Acute Febrile Illness Cases Through Machine Learning-Based Algorithm.
Cureus
November 2024
Pharmacology, All India Institute of Medical Sciences, Kalyani, IND.
Introduction Leptospirosis is a zoonotic infection caused by bacteria, which is reemerging in various regions and often poses a diagnostic challenge due to its nonspecific symptoms. While most infections are mild, severe cases occur in 5-10% of patients and are associated with high mortality, especially in areas with poor sanitation and urbanization. This study aims to investigate the association of specific parameters with leptospirosis diagnosis using a machine learning model and geographic mapping tools to identify spatial patterns and high-risk areas for the disease.
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