AI Article Synopsis
- A novel compound, a diazocan with dipeptide mimetic properties, was created through a specific chemical reaction involving Raney-Ni to break down a pyrazolidine structure.
- This compound features an 8-membered ring and includes a nitrogen component that aids in studying how its structure influences its activity.
- The effectiveness of this compound as an inhibitor of interleukin-1beta was tested in a cell-based assay to understand its potential use in medical applications.
Article Abstract
A novel diazocan containing dipeptide mimetic was synthesized via reductive N-N bond cleavage of a pyrazolidino-pyrazolidine using Raney-Ni and evaluated as an ICE inhibitor. This versatile 8-membered ring containing scaffold possesses an N-5 ring nitrogen that was used to explore structure-activity relationships in a cell-based assay measuring inhibition of interleukin-1beta.
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| http://dx.doi.org/10.1016/j.bmcl.2005.06.050 | DOI Listing |
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