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Design of a pseudo-color-assisted biocompatible supramolecular sensing probe for "lighting up" endogenous salicylic acid in plants.
Biosens Bioelectron
December 2024
College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, Heilongjiang 150040, PR China. Electronic address:
The widely recognized phytohormone, salicylic acid (SA), serves not only as an exogenous additive for fruits and vegetables but, more crucially, as an in vivo regulator of the entire plant growth process. Consequently, it is essential to achieve both in vitro detection and in vivo imaging analysis of the plant hormone SA. In this study, a biocompatible supramolecular probe was crafted using a "label-free" SA aptamer as the host for an aggregation-induced emission (AIE) organic small molecule.
View Article and Find Full Text PDFNew intrinsically unsymmetric aromatic donors (D) and acceptors (A) were designed to simplify the incorporation of a single reactive group. Naphthalene diimide (NDI) was desymmetrized by replacing one of the imide units with two nitro groups to yield 3,6-dinitronaphthalene monoimide (NMI(NO)); likewise, 3,6-dimethoxycarbazole (CBZ(OMe)) was designed as a 3-ring aromatic donor. Different derivatives of naphthalene monoimide (NMI) and carbazole (CBZ) were prepared, and charge-transfer complex formation between them was studied using NMR and UV-visible titrations; the estimated association constants () were compared with the common pair, NDI, and 1,5-dialkoxy naphthalene (DAN).
View Article and Find Full Text PDFSelf-healing hyaluronic acid/polylysine hydrogel prepared by dual-click chemistry from polyrotaxane slidable crosslinkers.
J Colloid Interface Sci
February 2025
The Key Laboratory of Biomedical Material, School of Life Science and Technology, Xinxiang Medical University, Xinxiang, PR China.
A new type of pH-sensitive hydrogel containing supramolecular structures was fabricated from maleimide-functionalized polyrotaxane, ɛ-polylysine and furan-functionalized hyaluronic acid by Diels-Alder reaction and amino-maleimide reaction. Firstly, pseudo polyrotaxane was obtained through self-assembly of polyethylene glycol and α-cyclodextrin, and then capped with 1-adamantanecarboxylic acid to convert it into polyrotaxane. Secondly, a maleimide-functionalized slidable crosslinker was obtained by modifying the polyrotaxane with 3-maleimide propionic acid, and furan-functionalized hyaluronic acid was prepared by modifying it with 2-furanmethylamine.
View Article and Find Full Text PDFHigh-throughput capture and in situ protein analysis of extracellular vesicles by chemical probe-based array.
Nat Protoc
October 2024
Center for Supramolecular Chemical Biology, State Key Laboratory of Supramolecular Structure and Materials, School of Life Sciences, Jilin University, Changchun, China.
Article Synopsis
- Extracellular vesicles (EVs) are tiny particles involved in cell communication and contain various biological materials like nucleic acids and proteins, making them significant for potential therapies and diagnostics.
- The new method introduced enhances the analysis of EVs from small sample amounts using an amphiphile-dendrimer supramolecular probe (ADSP) on a nitrocellulose membrane, allowing for efficient capture and profiling of EVs.
- This protocol enables high-throughput and reproducible analysis through automated printing and a quick process that includes capturing EVs in just 30 minutes and completing the immunoblotting assay within 3 hours.
Application of RET Approach for Ratiometric Response Enhancement of ICT Fluorescent Hg Probe based on Crown-containing Styrylpyridinium Dye.
Chem Asian J
December 2024
Laboratoty of Photoactive Supramolecular Systems, A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Vavilova str. 28, Moscow, 119334, Russia.
Article Synopsis
- A new compound, NI-SP, was created by linking a styrylpyridinium dye and a naphthalimide fluorophore using a "click" chemistry method.
- NI-SP shows a selective fluorescent response to mercury (Hg) in water, with the efficiency of detection improved through resonance energy transfer (RET) and intramolecular charge transfer (ICT).
- In biological tests, NI-SP was found to enter human lung cancer cells and effectively measure mercury levels within a concentration range of 0.7-6.0 μM.
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