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Molecule interacting with CasL-2 enhances tumor progression and alters radiosensitivity in cervical cancer.
J Transl Med
January 2025
Department of Radiation Oncology, The Second Affiliated Hospital of Dalian Medical University, No. 467 of Zhongshan Road, Shahekou District, Dalian, 116023, China.
Objective: Cervical cancer is a common malignancy among women, and radiotherapy remains a primary treatment modality across all disease stages. However, resistance to radiotherapy frequently results in treatment failure, highlighting the need to identify novel therapeutic targets to improve clinical outcomes.
Methods: The expression of molecule interacting with CasL-2 (MICAL2) was confirmed in cervical cancer tissues and cell lines through western blotting (WB) and immunohistochemistry (IHC).
Green synthesis, characterization, antioxidant, interaction with DNA/BSA, and investigation of cytotoxicity against MCF-7 cancer cells of zinc oxide nanoparticles using Hammada scoparia (Pomel) Iljin extract.
Int J Biol Macromol
January 2025
Nuclear Research Centre of Birine, Ain Oussera, Djelfa 17200, Algeria. Electronic address:
There is a need for advanced developments to battle aggressive breast cancer variations and to address treatment resistance. In cancer therapy, ZnO nanoparticles (NPs) possess the ability to selectively and effectively induce apoptosis in cancer cells. There is an urgent necessity to create novel anti-cancer therapies, and recent studies indicate that ZnO nanoparticles have significant promise.
View Article and Find Full Text PDFMelittin suppresses ovarian cancer growth by regulating SREBP1-mediated lipid metabolism.
Phytomedicine
January 2025
School of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address:
Background: Melittin, a major peptide component of bee venom, has demonstrated promising anti-cancer activity across various preclinical cell models, making it a potential candidate for cancer therapy. However, its molecular mechanisms, particularly in ovarian cancer, remain largely unexplored. Ovarian cancer is a life-threatening gynecological malignancy with poor clinical outcomes and limited treatment options.
View Article and Find Full Text PDFInvestigating the Impact of Circulating MicroRNAs on Knee and Hip Osteoarthritis: Causal Links, Biological Mechanisms, and Drug Interactions.
Int J Mol Sci
December 2024
Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100010, China.
Osteoarthritis (OA), particularly in the knee and hip, poses a significant global health challenge due to limited therapeutic options. To elucidate the molecular mechanisms of OA and identify potential biomarkers and therapeutic targets, we utilized genome-wide association studies (GWAS) and cis-miRNA expression quantitative trait loci (cis-miR-eQTL) datasets to identify miRNAs associated with OA, revealing 16 that were linked to knee OA and 21 to hip OA. Among these, hsa-miR-1303 was significantly upregulated in both knee and hip OA (IVW: = 6.
View Article and Find Full Text PDFDynamic Changes in Circulating Tumor DNA During Immunotherapy for Head and Neck Cancer: SHIZUKU-HN Study.
Int J Mol Sci
December 2024
Department of Medical Oncology, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-Ku, Tokyo 113-8510, Japan.
Immune checkpoint inhibitors (ICIs) are effective in treating recurrent/metastatic head and neck squamous cell carcinoma (HNSCC), but only 20% of patients achieve durable responses. This study evaluated circulating tumor DNA (ctDNA) as a real-time biomarker for monitoring treatment response in HNSCC. The SHIZUKU-HN study prospectively collected and analyzed serial plasma samples (n = 27) from HNSCC patients undergoing ICIs, using Guardant360 to assess ctDNA variant allele frequency (VAF) and genetic mutations.
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