In this study, we focus on the potential interaction of pp32/I-1(PP2A) (pp32) with the Raf-MEK-ERK signaling pathway. We show that overexpressed pp32 suppresses Raf-1 activation, thereby downregulating the level of ERK activation. This suppression of Raf-1 requires the C-terminal half of pp32. Conversely, knock-down of PP32 by siRNA enhances ERK and MEK activations. Taken together, we propose that tumor-suppression by pp32 is, at least in part, mediated by downregulation of the Raf-MEK-ERK signaling pathway.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.canlet.2004.11.026 | DOI Listing |
Publication Analysis
Top Keywords
raf-mek-erk signaling
8
signaling pathway
8
pp32
5
pp32/ i-1pp2a
4
i-1pp2a negatively
4
negatively regulates
4
regulates raf-1/mek/erk
4
raf-1/mek/erk pathway
4
pathway study
4
study focus
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!