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Stability of refractive outcomes after hyperopic LASIK with and without Mitomycin C application: a randomized controlled trial.

Sci Rep

January 2025

Department of Ophthalmology, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University, Moorenstraße 5, 40225, Dusseldorf, Germany.

To assess the efficacy, safety, and stability of refractive outcomes in hyperopic Laser-Assisted in Situ Keratomileusis (LASIK) with and without the application of Mitomycin C (MMC). This randomized, parallel group, controlled multicenter trial included 140 hyperopic eyes. The participants were randomly assigned to two groups: one receiving LASIK with mitomycin C (MMC) (n = 70) and the other receiving LASIK without MMC (n = 70).

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Anorexia nervosa (AN) is a psychiatric eating disorder characterized by body mass index (BMI) ≤ 18.5, fear of gaining weight, and a distorted perception of body weight. With increasing rates of myopia, there is a population of patients who concurrently develop AN and may seek corneal refractive surgery.

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Purpose: To evaluate the incidence and causes of the need for retreatment after LASIK-induced monovision in patients with myopia and presbyopia without a previous trial of contact lens induced monovision.

Design: Retrospective, observational study.

Methods: We retrospectively studied 914 eyes of 457 consecutive myopic patients with presbyopia scheduled for LASIK-induced monovision (nondominant eye corrected for near).

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Extreme myopic laser-assisted in situ keratomileusis (LASIK) poses challenges regarding future intraocular lens (IOL) power selection. A male patient in his 40s complained of progressive right eye (OD) diminished visual acuity. He had a history of myopic LASIK in both eyes (OU) 20 years before, and implantable collamer lens (ICL) implant in OU 8 years before.

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Purpose: To evaluate the performance of the InnovEyes Sightmap platform (Alcon Laboratories, Inc) in refractive surgery by comparing the visual acuity and higher order aberrations (HOAs) between ray-tracing-guided laser in situ keratomileusis (LASIK) and topography-guided LASIK.

Methods: This prospective study enrolled participants who underwent either ray-tracing-guided LASIK or topography-guided LASIK. Comprehensive ophthalmic evaluations were performed preoperatively, as well as at 1 day, 2 weeks, 1 month, and 3 months postoperatively.

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