Alertness was studied in adult male Wistar rats after neonatal critical anoxia applied under three different thermal conditions: (i) at physiological neonatal body temperature of 33 degrees C, (ii) at body temperature elevated to 37 degrees C, and (iii) at body temperature elevated to 39 degrees C (both during anoxia and for 2 h postanoxia). To elucidate the effect of iron-dependent postanoxic oxidative damage to the brain, half of the group (iii) was injected with deferoxamine, a chelator of iron. Postanoxic behavioural disturbances were recorded in open-field, elevated plus-maze, and sudden silence tests when the rats reached the age of 4 month. Moreover, spontaneous motor activity of the rats was recorded radiotelemetrically in their home-cages. Both open-field stress-induced and spontaneous motor activity were reduced in rats subjected to neonatal anoxia under hyperthermic conditions. In contrast, these rats were hyperactive in the plus-maze test. Both the plus-maze and sudden silence tests revealed that these rats show reduced alertness to external stimuli signalling potential dangers. The behavioural disturbances were prevented by the body temperature of 33 degrees C and by postanoxic administration of deferoxamine. These data support the conclusion that permanent postanoxic behavioural disturbances are due to iron-dependent oxidative damage to the brain, which can be prevented by the reduced neonatal body temperature.
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http://dx.doi.org/10.1016/j.bbr.2005.05.015 | DOI Listing |
J Exp Biol
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Ornis italica, Rome, Italy.
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View Article and Find Full Text PDFPLoS Biol
January 2025
Department of Biology, University of Washington, Seattle, Washington, United States of America.
Body size declines are a common response to warming via both plasticity and evolution, but variable size responses have been observed for terrestrial ectotherms. We investigate how temperature-dependent development and growth rates in ectothermic organisms induce variation in size responses. Leveraging long-term data for six montane grasshopper species spanning 1,768-3 901 m, we detect size shifts since ~1960 that depend on elevation and species' seasonal timing.
View Article and Find Full Text PDFInnovation (Camb)
September 2024
Department of Materials Science and Engineering, Southern University and Science and Technology, Shenzhen 518055, China.
The human skin maintains a comfortable and healthy somatosensory state by sensing different aspects of the thermal environment, including temperature value, heat source, energy level, and duration. However, state-of-the-art thermosensors only measure basic temperature values, not the full range of the thermosensation function of human skin. Here, we propose a heat source recognition () sensor of poly(butyl acrylate)-lithium bis(n-fluoroalkylsulfonyl)imide (PBA-Li:FSI; = 1, 3, 5), which enables response to temperature, pressure, and proximity stimulus signals based on the relaxation behavior of the ionic gel and distinguished between different types of heat sources (i.
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View Article and Find Full Text PDFEur J Med Res
January 2025
Department of Otolaryngology, Affiliated Hospital of Hebei University, 212th Yuhua Road, Baoding, Hebei, China.
The patient's body temperature significantly fluctuates, affected by factors, including anesthesia. The ideal temperature monitoring method that is suitable for perioperative application is of great significance for identifying hypothermia and malignant hyperthermia early, as well as for guiding intraoperative temperature protection. This study aims to compare the cutaneous zero-heat-flux (ZHF) thermometer application in general anesthesia using the infrared tympanic measurement as a reference.
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