AI Article Synopsis
- Recent progress has been made in understanding oral lichen planus (LP), but the exact causes and pathways of lesion formation are still unclear, creating challenges for clinical treatment.
- A consensus meeting in France in March 2003 addressed key issues, particularly the links between oral LP and viral infections like hepatitis C virus (HCV), as well as the immune mechanisms involved in the disease.
- The second part of the meeting report dealt with patient management strategies and treatment options, including concerns about the potential for malignant transformation of oral LP.
Article Abstract
Despite recent advances in understanding the immunopathogenesis of oral lichen planus (LP), the initial triggers of lesion formation and the essential pathogenic pathways are unknown. It is therefore not surprising that the clinical management of oral LP poses considerable difficulties to the dermatologist and the oral physician. A consensus meeting was held in France in March 2003 to discuss the most controversial aspects of oral LP. Part 1 of the meeting report focused on (1) the relationship between oral LP and viral infection, with special emphasis on hepatitis C virus (HCV), and (2) oral LP pathogenesis, in particular the immune mechanisms resulting in lymphocyte infiltration and keratinocyte apoptosis. Part 2 focuses on patient management and therapeutic approaches and includes discussion on malignant transformation of oral LP.
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| http://dx.doi.org/10.1016/j.tripleo.2004.06.076 | DOI Listing |
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