AI Article Synopsis
- The study investigates how topical treatments of prostacyclin and prostaglandin E1 affect the survival of skin flaps in rats exposed to nicotine.
- Rats were divided into four groups, with groups 1 and 2 receiving saline and nicotine, and groups 3 and 4 receiving prostacyclin or prostaglandin E1, respectively, after a nicotine treatment period.
- Results showed varying survival rates for the flaps, with both prostaglandin treatments enhancing survival compared to saline, and no significant difference in effectiveness between prostacyclin and prostaglandin E1.
Article Abstract
The aim of this study is to examine and compare the effects of topical prostacyclin and prostaglandin E1 on flap survival after nicotine application in rats. In the designed experiment, group 1 was treated with 1 mL saline, and groups 2, 3, and 4 were treated with 2 mg/kg of nicotine subcutaneously for 4 weeks. At the end of 4 weeks, surgery was done, and topical applications of vaseline base on groups 1 and 2, prostacyclin (PgI2-iloprost) on group 3, and prostaglandin E1 (PgE1-misoprostol) on group 4 were performed. At the end of the seventh day following the operation, all survival areas in all groups were identified. For groups 1, 2, 3, and 4, survival areas were measured as 59.05% +/- 5.13%, 50.40% +/- 4.74%, 67.89% +/- 4.69%, and 62.45% +/- 7.80%, respectively. As a result, the authors concluded that survival areas can be increased with topical applications of these prostaglandins on the flaps (that are under nicotine effect), and there were no differences between these 2 medications in terms of flap survival.
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| http://dx.doi.org/10.1097/01.sap.0000164533.22516.d9 | DOI Listing |
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