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The circulating plasma microRNA signature in human visceral leishmaniasis.
mSphere
January 2025
Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.
Visceral leishmaniasis (VL) is a vector-borne disease caused by the obligate intracellular protozoan in India. VL can be complicated by post-kala-azar dermal leishmaniasis (PKDL), a macular or nodular rash that develops in 10%-20% of patients after treatment of VL in India. Patients with PKDL are infectious to sand flies, promoting further transmission of the parasite.
View Article and Find Full Text PDFEarly transcriptomic changes at the skin interface during Powassan virus transmission by ticks.
Front Immunol
January 2025
Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, NY, United States.
Introduction: Powassan virus (POWV), a vector-borne pathogen transmitted by ticks in North America, is the causative agent of Powassan encephalitis. As obligate hematophagous organisms, ticks transmit pathogens like POWV at the tick bite site, specifically during the initial stages of feeding. Tick feeding and salivary factors modulate the host's immunological responses, facilitating blood feeding and pathogen transmission.
View Article and Find Full Text PDFPermanent Left Bundle Branch Area DF-4 Defibrillator Lead Implantation-Feasibility, Procedural Caveats, Safety, and Follow-Up.
J Cardiovasc Electrophysiol
January 2025
Department of Cardiac Electrophysiology and Pacing, Arrhythmia Heart Failure Academy, The Madras Medical Mission, Chennai, Tamil Nadu, India.
Introduction: Permanent implantation of a DF-4 implantable cardiac defibrillator (ICD) lead in the left bundle branch area (LBBA-ICD) is the next paradigm in amalgamating cardiac resynchronization therapy (CRT) and defibrillation. We systematically investigated feasibility/success rate, procedural caveats, and complications associated with a permanent DF-4 LBBA ICD implant and pertinent data at short-term follow-up.
Methods: We prospectively attempted implantation of 7 Fr Durata (Abbott, Chicago, IL, USA) single coil DF-4 ICD lead at the LBBA using a fixed-curve non-deflectable CPS locator delivery sheath.
Endosymbionts as hidden players in tripartite pathosystem of interactions and potential candidates for sustainable viral disease management.
Crit Rev Biotechnol
January 2025
Key Laboratory of Agricultural Microbiology, College of Agriculture, Guizhou University, Guiyang, P.R. China.
The convoluted relationships between plants, viruses, and arthropod vectors housing bacterial endosymbionts are pivotal in the spread of harmful plant viral diseases. Endosymbionts play key roles in: manipulating host responses, influencing insect resistance to pesticides, shaping insect evolution, and bolstering virus acquisition, retention, and transmission. This interplay presents an innovative approach for developing sustainable strategies to manage plant diseases.
View Article and Find Full Text PDFPharmacy students' opinion on mandatory summer internships carried out in community and hospital pharmacies.
BMC Med Educ
January 2025
Department of Humanities and Social Medicine, Medical University of Lublin, Lublin, Poland.
Background: Pharmacy internships are an important part of pharmacy education in Poland; they are an integral part of professional studies. The first two internships are held after the third and fourth year of study during the summer break and last for four weeks. The study aims to analyze the didactic process of the pharmacy students taking place during the summer internship in community and hospital pharmacies in Poland.
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