Purpose: Changes in low-density-lipoprotein cholesterol (LDL-C) levels and rates of LDL-C goal attainment among dyslipidemic patients newly referred to a telephone-based hyperlipidemia disease management program were studied.
Methods: The medical records of all patients referred to a hyperlipidemia disease management program between February 2002 and May 2003 were retrospectively reviewed. Patients were included in the study if they were between 18 and 80 years of age, were under the continuous care of a physician during the data collection period, had a baseline LDL-C measurement within the year before program enrollment, and had been assigned to a treatment protocol (low- or high-risk primary prevention, secondary prevention, or diabetes). For each patient, the final cholesterol value after six months of enrollment or the first value at goal was used to evaluate response. Subjects were deemed to have reached their goal if an LDL-C value recorded within six months after enrollment corresponded to national guidelines for their assigned protocol.
Results: Of 276 patients enrolled in the program, 205 were eligible for study. Forty-two patients (20.5%) were assigned to the secondary-prevention group, 69 (33.7%) to the diabetes group, 46 (22.4%) to the high-risk primary-prevention group, and 48 (23.4%) to the low-risk primary-prevention group. Overall LDL-C goals were attained by 76.2% of secondary-prevention patients, 56.5% of diabetes patients, 58.7% of high-risk primary-prevention patients, and 81.3% of low-risk primary-prevention patients.
Conclusion: LDL-C goal-attainment rates increased in patients referred to a telephone-based hyperlipidemia management program.
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http://dx.doi.org/10.2146/ajhp040343 | DOI Listing |
Breast Cancer Res Treat
January 2025
Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Purpose: To evaluate the prognostic significance of changes in pre- and post-neoadjuvant chemotherapy (NACT) Ki67 in patients with primary invasive triple-negative breast cancer (TNBC).
Methods: Population-based registry data were retrieved for patients diagnosed with TNBC between 2007 and 2021 (n = 9262). Multivariable Cox regression analysis was performed for disease-specific survival (DSS) and overall survival (OS) adjusted for age and residual disease in the breast and nodes (RDBN).
J Orthop Surg Res
January 2025
Department of Human Anatomy, Graduate School, Inner Mongolia Medical University, Hohhot, 010010, Inner Mongolia, China.
Purpose: The study aimed to develop a deep learning model for rapid, automated measurement of full-spine X-rays in adolescents with Adolescent Idiopathic Scoliosis (AIS). A significant challenge in this field is the time-consuming nature of manual measurements and the inter-individual variability in these measurements. To address these challenges, we utilized RTMpose deep learning technology to automate the process.
View Article and Find Full Text PDFOrphanet J Rare Dis
January 2025
Department of Genetics and Metabolism, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, No. 3333 Binsheng Road, Binjiang District, Hangzhou, 310053, Zhejiang, China.
Purpose: To enhance the detection rate of Neonatal Intrahepatic Cholestasis caused by Citrin Deficiency (NICCD) through newborn screening (NBS), we analyzed the metabolic profiles of missed patients and proposed a more reliable method for early diagnosis.
Methods: In this retrospective study, NICCD patients were classified into "Newborn Screening" (64 individuals) and "Missed Screening" (52 individuals) groups. Metabolic profiles were analyzed using the non-derivatized MS/MS Kit, and genetic mutations were identified via next-generation sequencing and confirmed by Sanger sequencing.
BMC Nephrol
January 2025
Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Key Laboratory of Organ Transplantation, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Huazhong University of Science and Technology, Ministry of Education, Chinese Academy of Medical Sciences, Wuhan, China.
Background: Effective treatment of late antibody-mediated rejection (late AMR) is still an unmet medical need. Clearing donor-specific antibody (DSA) and preventing its rebound is the ideal goal of treatment.
Methods: We have summarized the clinical data from seven patients with late or chronic active AMR after renal transplantation who received daratumumab (Dara)-based treatment first (Phase 1) and then tocilizumab (TCZ) therapy (Phase 2).
BMC Prim Care
January 2025
Département de psychiatrie, Centre de recherche de l'Institut universitaire en santé mentale de Montréal, Université de Montréal, Montreal, QC, Canada.
Objectives: This study identified profiles of outpatient physician follow-up care and other practice features, mostly after detection of incident mental disorders (MD), and associated these profiles with patient characteristics and subsequent adverse outcomes.
Methods: A cohort of 170,957 patients age 12 + with a new or recurrent MD detected in 2019-20 was investigated based on data from the Quebec Integrated Chronic Disease Surveillance System. Latent class analysis was performed to identify follow-up care profiles, mostly within one year of MD detection.
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