AI Article Synopsis
- - Cholesterol-modified oligonucleotides were created to explore how they interact with antisense oligonucleotides and cationic liposomes.
- - The study found that electrostatic interactions are crucial for the successful combination of these oligonucleotides with cationic lipids.
- - This new formulation led to a modest improvement in reducing P-glycoprotein expression in cells, indicating a potential for enhanced therapeutic effects.
Article Abstract
Cholesterol modified mono-, di-, and tetrameric oligonucleotides were synthesized and hybridized with antisense oligonucleotides to study their incorporation in cationic liposomes together with the influence of this dendrimeric delivery system on biological activity. Electrostatic interactions seem to play the most important role during complexation with cationic lipids. This oligonucleotide formulation gives a small but significant increase in the inhibition of P-glycoprotein expression in a cellular system.
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| http://dx.doi.org/10.1021/bc050022g | DOI Listing |
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