The aim of the authors is to discover the progress in the methodology for the interruption of pregnancy by medical indications during the second trimester in Gynecological clinic in UMBAL - Pleven. A retrospective study has been performed for the used methods in the last 10 years. For the same period were performed abortions in 49 women by medical indications. The interruption of pregnancy until the 16th gestational week (g.w.) of gestation was performed in one-stage. From the 16th g.w. to the 20th g.w., the most common method till the year 2001 was intraamniotic instillation of 25% solution of NaCl by Aburel (1934). After the 20th g.w. the pregnancy was interrupted either by metrierasis (using balloon catheter), or by sectio parva. After the 2001 was described radical change in conduct by therapeutic abortion during the second trimester, after the beginning of the prostaglandins use in obstetrical practice. The authors analyze the results of the use of prostaglandins describing the type, dosage of used medicine, period of abortion, contraindications and the risk for the mother. They reach to the conclusion that the prostaglandins are presently suitable means for therapeutical abortion during the second trimester, which fully replace the classical, traumatically and risky methods for the pregnant woman.

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