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The synthesis and flash column chromatographic separation of enantiomerically pure tris-adducts of C60 with an e,e,e-addition pattern is achieved via cyclopropanation with chiral D3-symmetrical cyclo-tris(malonate) tethers.
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http://dx.doi.org/10.1039/b502822a | DOI Listing |
Chem Asian J
December 2024
Govt. Degree College for Men, Srikakulam, Department of Chemistry, Srikakulam, 532001, Srikakulam, INDIA.
The production of enantiomerically pure compounds remains a vital and valuable objective in modern organic chemistry due to their broad applications in fields such as biosensing, optics, electronics, photonics, catalysis, nanotechnology, and drug or DNA delivery. Optically pure α-hydroxy ketones, in particular, are key structural components in many drugs and natural products with significant biological activity. Among these, benzoin type α-hydroxy ketones, which possess two adjacent functional groups, a carbonyl and a hydroxy group, are especially important.
View Article and Find Full Text PDFCryst Growth Des
December 2024
Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.
Organometallic antimony(V) complexes were prepared as model compounds to better understand the interactions of chiral chelating diols with this metalloid. These complexes feature three aryl groups (-xylyl or -tolyl) and a bidentate -2,3-butanediolate. The -xylyl and -tolyl complexes of either enantiomerically pure 2,3-butanediolate or 2,3-butanediolate (compounds -) crystallized in Sohncke space groups, as expected.
View Article and Find Full Text PDFArch Biochem Biophys
December 2024
Department of Biology and Biotechnology, University of Pavia, via Ferrata 9, 27100 Pavia, Italy. Electronic address:
Bacterial monoamine oxidases (MAOs) are FAD-dependent proteins catalyzing a relevant reaction for many industrial biocatalytic applications, ranging from production of enantiomerically pure building blocks for pharmaceutical synthesis to biosensors for monitoring food and beverage quality. The thermostable MAO enzyme from Thermoanaerobacterales bacterium (MAO) is about 36% identical to both putrescine oxidase and human MAOs and can be efficiently produced in Escherichia coli. MAO preferentially acts on n-alkyl monoamines but shows detectable activity also on polyamines and aromatic monoamines.
View Article and Find Full Text PDFCommun Chem
December 2024
Department of Chemistry, University of Zurich, Zurich, Switzerland.
Chirality plays a critical role in the biochemistry of life and often only one enantiomeric series is observed (homochirality). Only a few natural products have been obtained as racemates, e.g.
View Article and Find Full Text PDFPhytochemistry
December 2024
Department of Crop and Soil Science, North Carolina State University, Raleigh, NC, USA. Electronic address:
Plant species can accumulate secondary metabolites in optically pure form or, occasionally, as enantiomeric mixtures. Interestingly, enantiomers of the same molecule can confer different biological activities. In tobacco (Nicotiana tabacum L.
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