We studied the allergic and immunotoxic effects of a new promising medicinal preparation calcium ketopantoyl aminobutyrate. Calcium ketopantoyl aminobutyrate produced no negative effects on general mechanisms of humoral and cellular immunity. This preparation did not modulate the anaphylactic reaction to bovine serum, exhibited no mitostatic and lymphotoxic properties, had no effect on the delayed-type hypersensitivity response, and did not produce active cutaneous anaphylactic reaction.
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College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, 310012, China; Collaborative innovation center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, 310032, China. Electronic address:
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View Article and Find Full Text PDF[Antihypoxant and antiamnesic effects of calcium ketopantoylaminobutyrate].
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Experimental investigation of calcium ketopantoylaminobutyrate (Ca-KPAB), a new drug with a structure close to that of pantogam, showed that Ca-KPAB exhibits a pronounced antihypoxant effect on the normobaric and histotoxic hypoxia models. The new drug also produced a more pronounced antiamnesic action as compared to that of pantogam. A significant decrease in the effective drug dose in the case of Ca-KPAB is explained by its ability to readily bypass the blood - brain barrier.
View Article and Find Full Text PDFPotential mutagenicity, embryotoxicity, and teratogenicity of calcium ketopantoyl aminobutyrate.
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We studied mutagenic, embryotoxic, and teratogenic properties of calcium ketopantoyl aminobutyrate, a preparation proposed as a new drug. Long-term oral administration of calcium ketopantoyl aminobutyrate produced no mutagenic, embryotoxic, and teratogenic effects.
View Article and Find Full Text PDFAllergic and immunotoxic effects of calcium ketopantoyl aminobutyrate.
Bull Exp Biol Med
April 2005
Laboratory of Pharmacology, State Research Institute of Vitamins, Russia.
We studied the allergic and immunotoxic effects of a new promising medicinal preparation calcium ketopantoyl aminobutyrate. Calcium ketopantoyl aminobutyrate produced no negative effects on general mechanisms of humoral and cellular immunity. This preparation did not modulate the anaphylactic reaction to bovine serum, exhibited no mitostatic and lymphotoxic properties, had no effect on the delayed-type hypersensitivity response, and did not produce active cutaneous anaphylactic reaction.
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