[Screening for new binding proteins which interact with BM2 of influenza B virus with yeast two-hybrid system].

Objective: To explore the role of BM2 protein in the life cycle of influenza B virus.

Methods: The authors screened human kidney MATCHMAKER cDNA library for new binding partners of BM2 of influenza B virus by using the yeast two hybrid system with truncated BM2 (26-109 aa) as the bait.

Results: Six positive plasmids encoding N-acetylneuraminate pyruvate lyase, angiopoietin 3, zinc finger protein 251, ribosomal protein S20, protein arginine N-methyltransferase 1 variant 1 (PRMT) and transcription factor-like 1 (TCFL1) were obtained.

Conclusion: The results suggest that BM2 may play an important role in the life cycle of influenza B virus.