Purpose: To investigate the clinical features, visual function outcomes, and adverse events in patients with diffuse unilateral subacute neuroretinitis (DUSN) treated with high-dose oral albendazole.
Design: Interventional case series.
Methods: Twelve Brazilian patients, aged 7 through 36 years, with active DUSN in the early or late clinical stage, were recruited for this study between 1999 and 2001. A small variant motile worm was found in 4 (33.3%) of these cases. All patients were treated exclusively with high-dose oral albendazole (400 mg/d) for 30 days.
Results: Improvement of visual acuity, visual field, and active ocular inflammatory signs was observed in all patients after 4 weeks of treatment (median follow-up: 3 years). Also, during the first weeks of treatment, evidence of worm inactivation was documented for the four patients with visible worms. No adverse drug side effects were observed in any of our cases during follow-up.
Conclusion: High-dose oral albendazole seems to be safe and beneficial for patients with DUSN.
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http://dx.doi.org/10.1016/j.ajo.2005.03.065 | DOI Listing |
AAPS PharmSciTech
January 2025
School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
Albendazole serves as a broad-spectrum anthelmintic medication for treating hydatid cysts and neurocysticercosis. However, its therapeutic effectiveness is limited by poor solubility. Nanocrystals offer a promising technology to address this limitation by enhancing drug solubility.
View Article and Find Full Text PDFJ Agric Food Chem
January 2025
Laboratory of Veterinary Drug Development and Evaluation, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.
This study aimed to evaluate the pharmacokinetics and tissue distribution of albendazole (ABZ) and its three metabolites─albendazole sulfoxide (ABZSO), albendazole sulfone (ABZSO), and albendazole-2-aminosulfone (ABZ-2-NH-SO)─in Yellow River carp () reared at 17.2 ± 1.1 °C after single oral administration of 12 mg/kg body weight (BW) ABZ.
View Article and Find Full Text PDFFront Vet Sci
December 2024
Guangdong Key Laboratory for Veterinary Drug Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University (SCAU), Guangzhou, China.
Albendazole (ABZ), classified as a class II basic drug under the Biopharmaceutics Classification System (BCS), is widely recognized for its therapeutic efficacy in treating and preventing trichuriasis. However, despite its clinical relevance, ABZ's oral administration presents challenges due to its poor solubility and pH sensitivity, which diminish its therapeutic effectiveness. Additionally, high dosing regimens of ABZ pose risks of developmental toxicity in animal models.
View Article and Find Full Text PDFIran J Parasitol
January 2024
Department of Chest Diseases, School of Medicine, Hacettepe University, Ankara, Turkey.
remains a global public health issue. Although predominantly affecting the liver, the lungs are the second most affected organ and often undergo surgical intervention. Here, a case managed by bronchoscopy and medical therapy is presented.
View Article and Find Full Text PDFPediatr Dermatol
December 2024
Department of Dermatology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Vulvovaginal enterobiasis is underreported and an often-missed diagnosis in prepubertal girls presenting with isolated nocturnal vulvar pruritus. An 8-year-old-girl with intense nocturnal vulvar itching for 4 months was diagnosed with enterobiasis after microscopy of a vaginal swab revealed Enterobius vermicularis (pinworm) ova. The child and her family were treated with two doses of oral albendazole, 2 weeks apart, resulting in symptom resolution.
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