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Peripheral immune characteristics and subset disorder in reproductive females with endometriosis.
Front Immunol
December 2024
Institute of Translational Medicine, The First People'sHospital of Foshan, Foshan, Guangdong, China.
Pathogenesis of endometriosis (EN) is still unknown, but growing evidence suggests that immune regulation may be important, and the pattern of peripheral immune changes in reproductive women with EN has yet to be fully explored. In this study, we conducted a comprehensive and systematic analysis of immune cell subsets within T cells, B cells, NK cells, and γδ T cells in peripheral blood (PB) samples from women with EN, women with uterine fibroids (UF) but without EN (UF-alone), and healthy controls using multi-parameter flow cytometry. Our findings revealed that UF, a common comorbidity of EN, exhibited similar peripheral immune features to EN, particularly in T cell and B cell immunity.
View Article and Find Full Text PDFImmunologic Crosstalk and Host-Specific Immune Signature Associated with Dengue.
ACS Omega
September 2024
Department of Microbiology, NRS Medical College, Kolkata, West Bengal 700 014, India.
In tropical and subtropical regions, dengue fever is a common febrile illness that is mostly spread by Aedes mosquitoes. Urban population migration, inadequate water storage facilities, and high mosquito density are features associated with this disease. The severity of the illness ranges from mild to deadly dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), often with severe cases causing profound shock from extensive plasma leakage, and may result in demise.
View Article and Find Full Text PDFTherapeutic glycan-specific antibody binding mediates protection during primary amoebic meningoencephalitis.
Infect Immun
October 2024
Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA.
() infection the upper respiratory tract causes a fatal CNS disease known as primary amoebic meningoencephalitis (PAM). The robust immune response to underlies the immunopathology that characterizes the disease. However, little is known about why this pathogen evades immune control.
View Article and Find Full Text PDFThe immunologic role of IL-23 in psoriatic arthritis: a potential therapeutic target.
Expert Opin Biol Ther
October 2024
Department of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Introduction: Psoriatic arthritis (PsA) is a debilitating chronic condition characterized by inflammation of the joints, bones, enthesis, and skin. The pivotal role of interleukin-23 (IL-23) in the pathogenesis of PsA has become increasingly evident. This proinflammatory cytokine is markedly elevated in patients with PsA, suggesting its potential as a therapeutic target.
View Article and Find Full Text PDFSynergy Between NK Cells and Monocytes in Potentiating Cardiovascular Disease Risk in Severe COVID-19.
Arterioscler Thromb Vasc Biol
October 2024
Department of Microbial Infection and Immunity, College of Medicine (M.G., M.A., Y.W., W.M., K.W., S.-L.L., N.P.M.L.), The Ohio State University, Columbus.
Background: Evidence suggests that COVID-19 predisposes to cardiovascular diseases (CVDs). While monocytes/macrophages play a central role in the immunopathogenesis of atherosclerosis, less is known about their immunopathogenic mechanisms that lead to CVDs during COVID-19. Natural killer (NK) cells, which play an intermediary role during pathologies like atherosclerosis, are dysregulated during COVID-19.
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