Skin preservation for transplantation began almost 200 years ago with the pioneering work of Baronio (cited by in Ref. ). Since that time, hundreds of papers have been published on the preservation of skin for later application in wound treatment. This interest stems from the excellent clinical results obtained with skin as a permanent autograft or temporary allograft for wound cover, coupled with the relative ease of preservation and storage methods. The general recognition of the need for human skin allografts has stimulated the establishment of banking facilities and research to improve the methods for harvesting, processing, storage, and subsequent evaluation of transplantation performance.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.clindermatol.2004.07.021 | DOI Listing |
J Am Podiatr Med Assoc
January 2025
†Jesse Brown VA Medical Center, Chicago, IL.
Tissue selective ultrasonic debridement is a new method of debriding chronic wounds that prepares the wound for advanced tissue application. This article presents the case of an 89-year-old woman with a chronic nonhealing wound to her lateral distal leg. The wound had a significant amount of biofilm and fibrous slough.
View Article and Find Full Text PDFFront Immunol
January 2025
Section of Immunology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Background: Maintenance immunosuppression is required for suppression of alloimmunity or allograft rejection. However, continuous use of immunosuppressants may lead to various side effects, necessitating the use of alternative immunosuppressive drugs. The early secreted antigenic target of 6 kDa (ESAT-6) is a virulence factor and immunoregulatory protein of mycobacterium tuberculosis (Mtb), which alters host immunity through dually regulating development or activation of various immune cells.
View Article and Find Full Text PDFInt J Burns Trauma
December 2024
School of Medicine, Islamic Azad University, Najafabad Branch Isfahan, Iran.
The management of complex burn injuries has evolved significantly, with various surgical techniques developed to improve outcomes. This review examines the evolution of these methods, focusing particularly on mesh grafting and the Meek technique. While mesh grafting is effective, it poses challenges such as limited graft coverage and a high demand for autologous skin.
View Article and Find Full Text PDFAnn Plast Surg
January 2025
Division of Plastic Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL.
Background: Nasal septal defects cause considerable morbidity and represent a challenging reconstructive problem. Traditional repair techniques have employed local intranasal tissues and allograft adjuncts. For large septal defects (>4-5 cm2), less than half are successfully resolved.
View Article and Find Full Text PDFAm J Transplant
January 2025
Department of Surgery, Division of Plastic Surgery, Yale School of Medicine, New Haven, CT, USA. Electronic address:
Rejection monitoring in facial vascularized composite allotransplantation (fVCA) traditionally focuses on skin biopsies. However, mucosal rejection frequently presents with more pronounced signs of immune activity. To explore mechanistic differences between skin and mucosal rejection, rejection and non-rejection biopsies from allograft skin and oral mucosa of nine fVCA recipients were retrospectively analyzed using histology, multiplex immunostaining, and gene expression profiling, with peripheral blood mononuclear cells (PBMCs) quantified via mass cytometry (CyTOF).
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!