AI Article Synopsis
- FXR is important for regulating glucose levels during fasting, as shown by differences between FXR-deficient and wild-type mice.
- FXR-deficient mice experience faster hypoglycemia, lower hepatic glucose production, and reduced glycogen stores compared to their wild-type counterparts.
- The study indicates that FXR influences the expression of critical genes involved in glucose production, affecting overall energy availability during fasting.
Article Abstract
The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To determine whether FXR modulates the response to fasting in vivo, FXR-deficient (FXR-/-) and wild-type mice were submitted to fasting for 48 h. Our results demonstrate that FXR modulates the kinetics of alterations of glucose homeostasis during fasting, with FXR-/- mice displaying an early, accelerated hypoglycaemia response. Basal hepatic glucose production rate was lower in FXR-/- mice, together with a decrease in hepatic glycogen content. Moreover, hepatic PEPCK gene expression was transiently lower in FXR-/- mice after 6h of fasting and was decreased in FXR-/- hepatocytes. FXR therefore plays an unexpected role in the control of fuel availability upon fasting.
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| http://dx.doi.org/10.1016/j.febslet.2005.06.033 | DOI Listing |
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