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Transcranial Endovascular Embolization of Dural Arteriovenous Fistula: A Case Report and Literature Review.
Cureus
July 2024
Interventional Neuroradiology, Hospital Corporation of America (HCA) Southern Hills Hospital, Las Vegas, USA.
Article Synopsis
- * It outlines the authors' experience with a transcranial endovascular approach as a solution for these difficult cases.
- * The findings suggest that this method is both safe and effective for treating dAVF when other access routes aren't viable.
Ischemic Stroke due to Intracranial Embolization of a Pelvic Phlebolith in a Pregnant Patient Successfully Treated by Surgical Embolectomy following Attempted Endovascular Thrombectomy.
Case Rep Radiol
December 2023
HCA Mountainview Hospital Sunrise Health GME Consortium, Department of Radiology, USA.
An unusual case of ischemic stroke due to calcified cerebral embolus occurring in a pregnant patient during the peripartum period is reported. The source of the embolus was suspected to be a pelvic phlebolith in origin which paradoxically embolized via a patent foramen ovale to the supraclinoid right internal carotid artery. To our knowledge, this is the first reported case of calcified cerebral embolus attributed to paradoxical embolism of a pelvic phlebolith, and we theorize that introduction of the phlebolith into the venous system may have occurred as a consequence of vascular remodeling due to pregnancy-related hemodynamic changes.
View Article and Find Full Text PDFNew indicators and indexes for benchmarking university-industry-government innovation in medical and life science clusters: results from the European FP7 Regions of Knowledge HealthTIES project.
Health Res Policy Syst
January 2019
Sir William Dunn School, University of Oxford, Oxford, United Kingdom.
Background: While the European Union is striving to become the 'Innovation Union', there remains a lack of quantifiable indicators to compare and benchmark regional innovation clusters. To address this issue, a HealthTIES (Healthcare, Technology and Innovation for Economic Success) consortium was funded by the European Union's Regions of Knowledge initiative, research and innovation funding programme FP7. HealthTIES examined whether the health technology innovation cycle was functioning differently in five European regional innovation clusters and proposed regional and joint actions to improve their performance.
View Article and Find Full Text PDFAutoantibodies targeting TLR and SMAD pathways define new subgroups in systemic lupus erythematosus.
J Autoimmun
July 2018
Department of Medical and Molecular Genetics, King's College London, London, SE1 9RT, UK. Electronic address:
Objectives: The molecular targets of the vast majority of autoantibodies in systemic lupus erythematosus (SLE) are unknown. We set out to identify novel autoantibodies in SLE to improve diagnosis and identify subgroups of SLE individuals.
Methods: A baculovirus-insect cell expression system was used to create an advanced protein microarray with 1543 full-length human proteins expressed with a biotin carboxyl carrier protein (BCCP) folding tag, to enrich for correctly folded proteins.
A germline mutation of CDKN2A and a novel RPLP1-C19MC fusion detected in a rare melanotic neuroectodermal tumor of infancy: a case report.
BMC Cancer
August 2016
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford, OX3 7HE, UK.
Article Synopsis
- Melanotic neuroectodermal tumor of infancy (MNTI) is very rare, mainly found in the head and neck, with this case being the first in the fibula and only the eighth instance of occurrence in an extremity.
- A 2-month-old girl presented with a fibula mass; thorough testing revealed no mutations but identified a loss of function mutation in the CDKN2A gene, along with chromosomal translocations and gene fusions that may deregulate tumor-related microRNA genes.
- The findings suggest that MNTI's aggressive form in infants could stem from a genetic mutation combined with tumor-promoting gene fusions and epigenetic changes, highlighting the limited understanding of this rare tumor type
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