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Advancing vaccine technology through the manipulation of pathogenic and commensal bacteria.
Mater Today Bio
December 2024
College of Veterinary Medicine, Jeonbuk National University, 79 Gobong-ro, Iksan City, Jeollabuk-do, 54596, Republic of Korea.
Advancements in vaccine technology are increasingly focused on leveraging the unique properties of both pathogenic and commensal bacteria. This revolutionary approach harnesses the diverse immune modulatory mechanisms and bacterial biology inherent in different bacterial species enhancing vaccine efficacy and safety. Pathogenic bacteria, known for their ability to induce robust immune responses, are being studied for their potential to be engineered into safe, attenuated vectors that can target specific diseases with high precision.
View Article and Find Full Text PDFUnified approaches in transition metal catalyzed C(sp)-H functionalization: recent advances and mechanistic aspects.
Chem Soc Rev
January 2025
Department of Chemistry, IIT Bombay, Powai, Mumbai-400076, India.
In organic synthesis, C(sp)-H functionalization is a revolutionary method that allows direct alteration of unactivated C-H bonds. It can obviate the need for pre-functionalization and provides access to streamlined and atom economical routes for the synthesis of complex molecules starting from simple starting materials. Many strategies have evolved, such as photoredox catalysis, organocatalysis, non-directed C-H activation, transiently directed C-H activation, and native functionality directed C-H activation.
View Article and Find Full Text PDFNiosomal Encapsulation of Anti-Cancer Peptides: A Revolutionary Strategy in Cancer Therapy.
Curr Pharm Biotechnol
January 2025
Department of Pharmaceutical Chemistry and Analysis, Ramanbhai Patel College of Pharmacy, Charotar University of Science & Technology, CHARUSAT At- Changa, Dist- Anand, Ta- Petlad, Pin-388421.
Cancer treatment has evolved significantly over the years, incorporating a range of modalities including surgery, radiation, chemotherapy, and immunotherapy. However, challenges such as drug resistance, systemic toxicity, and poor targeting necessitate innovative approaches. Peptides have gained attention in cancer therapy due to their specificity, potency, and ability to modulate various biological pathways.
View Article and Find Full Text PDFWhence the birds: 200 years of dinosaurs, avian antecedents.
Biol Lett
January 2025
Department of Earth Sciences, University of Cambridge, Cambridge, UK.
Among the most revolutionary insights emerging from 200 years of research on dinosaurs is that the clade Dinosauria is represented by approximately 11 000 living species of birds. Although the origin of birds among dinosaurs has been reviewed extensively, recent years have witnessed tremendous progress in our understanding of the deep evolutionary origins of numerous distinctive avian anatomical systems. These advances have been enabled by exciting new fossil discoveries, leading to an ever-expanding phylogenetic framework with which to pinpoint the origins of characteristic avian features.
View Article and Find Full Text PDFRecent advances in innovative biomaterials for promoting bladder regeneration: processing and functionalization.
Front Bioeng Biotechnol
January 2025
The Second Hospital of Jilin University, Changchun, China.
The bladder is a dynamic organ located in the lower urinary tract, responsible for complex and important physiological activities in the human body, including collecting and storing urine. Severe diseases or bladder injuries often lead to tissue destruction and loss of normal function, requiring surgical intervention and reconstruction. The rapid development of innovative biomaterials has brought revolutionary opportunities for modern urology to overcome the limitations of tissue transplantation.
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