Purpose: To search for individualized scan protocols that provide adequate diagnostic information with minimal radiation exposure for abdominal CT in adults.
Material And Methods: Beginning with standard settings (120 kVp, 200 mA, 0.75 s, CTDI (w = 11.7 mGy)), which are in the lowest quartile of the actual German radiation dose survey, 119 adults were examined using a single-row detector helical CT with 8 mm collimation and a pitch of 1.5. The individualized scan protocol was defined by repeating the reference scan up to 3 times with different radiation doses following a predefined iteration scheme. The image qualities with standard dose and with individualized dose were assessed independently by 3 radiologists blinded to the exposure parameters. The individualized dose was correlated with the diameter of the patients.
Results: The patient diameters varied from 16 to 35 cm and correlated with individualized radiation doses CTDI (w) from 6.4 to 17.6 mGy. We found an exponential correlation (y = 52.3 x e (0.05 x); r(2) = 0.48; p < 0.001) between required tube current (mA) and a. p. diameter (cm) in the epigastric region in adults.
Conclusion: Maintaining constant exposure parameters results in unnecessary radiation exposure in patients with a diameter of less than 27 cm measured in anterior-posterior direction in the epigastric area. The radiation exposure in adult abdominal CT can be reduced up to 45 % by individualized selection of the tube current without adversely affecting diagnostic performance.
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http://dx.doi.org/10.1055/s-2005-858323 | DOI Listing |
Cancer Med
February 2025
Brigham and Women's Hospital, Boston, Massachusetts, USA.
Introduction: Given the known detrimental impact of cancer treatment on fertility, fertility preservation (FP) is recommended for reproductive age patients who are newly diagnosed with cancer. However, the rate of referral to fertility specialists remains suboptimal. The objective of this study was to determine the impact of a dedicated Nurse Navigator Program (NNP) on the rate of referrals and utilization of FP services.
View Article and Find Full Text PDFJ Biochem Mol Toxicol
February 2025
College of Medicine, Al-Ayen Iraqi University, An Nasiriyah, Iraq.
Cancer ranks as the second leading cause of death in the United States and poses a significant health challenge globally. Numerous therapeutic options exist for treating cancer, with chemotherapy being one of the most prominent. Chemotherapy involves the use of antineoplastic drugs, either alone or in combination with other medications, to target and kill cancer cells.
View Article and Find Full Text PDFEnviron Toxicol Chem
January 2025
Department of Health Sciences, "Magna Græcia University" of Catanzaro, Catanzaro, Italy.
Perfluorooctanesulfonate (PFOS) is a widely used chemical that accumulates in living things and the environment, especially the aquatic, over time. It is also known as a "forever chemical". Furthermore, different anthropogenic substances are rarely found individually in the environment.
View Article and Find Full Text PDFJ Natl Cancer Inst
January 2025
Department of Neurological Surgery, Washington University School of Medicine, St Louis, MO, USA.
Background: World Health Organization Grade 2 meningiomas (G2Ms) often recur and resist therapies. G2Ms with histopathological necrosis have been associated with worse local control (LC) following radiation therapy, but the drivers and biomarkers of radiation resistance in G2Ms remain unknown.
Methods: We performed genetic sequencing and histopathological analysis of 113 G2Ms and investigated the role of genetic and microenvironmental factors on clonogenic survival following ionizing radiation.
Cureus
December 2024
Internal Medicine, University of Alexandria, Alexandria, EGY.
Aim: Thyroid nodules, based on high-resolution ultrasonography (HRUS), are among the most common endocrine abnormalities that affect the general population because of their high estimated prevalence rates. Fine needle aspiration cytology (FNAC) is a safe, cost-effective modality to differentiate between benign and malignant thyroid nodules based on the Bethesda System for Reporting Thyroid Cytopathology (BSRTC), thus avoiding unnecessary surgery. However, categories III and IV of BSRTC remain a controversial issue in clinical practice, encompassing a wide range of risks of malignancy.
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