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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
School of Pharmacy, Chapman University, Irvine, CA, USA.
Background: Chronic heavy alcohol drinking may be a modifiable risk factor for Alzheimer's disease (AD), but studies in rodent AD models more closely mimic chronic moderate alcohol drinking in humans and largely focus on the brain. The role of the liver, which is significantly impacted by chronic heavy alcohol intake, in driving brain changes in alcohol-dependent AD remains unexplored. Our study using intragastric-ethanol feeding, which mimics chronic heavy alcohol intake in humans, in C57BL/6J mice showed significant AD-relevant changes in the brain and liver.
View Article and Find Full Text PDFHepatic Amyloidosis Without Hepatomegaly.
Dig Dis Sci
December 2024
Department of Hepatology, Mengchao Hepatobiliary Hospital of Fujian Medical University, No.312, Xihong Road, Fuzhou, 350025, Fujian, China.
Successful transarterial embolization of hemorrhage following percutaneous liver biopsy in hepatic amyloidosis.
Clin Case Rep
October 2024
Department of Diagnostic and Therapeutic Radiology, Faculty of Medicine Ramathibodi Hospital, Mahidol University Bangkok Thailand.
Percutaneous liver biopsy is essential for diagnosing hepatic amyloidosis. Post biopsy hemorrhage is unusual but can occur. The potential for bleeding can result from various factors, such as the deposition of amyloid in the hepatic parenchyma or vessel wall, deficiencies in coagulation factors, hyperfibrinolysis, and platelet dysfunction.
View Article and Find Full Text PDFSystemic Amyloidosis Presenting as Budd-Chiari Syndrome: A Case Report.
Middle East J Dig Dis
July 2024
Department of Gastroenterology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Article Synopsis
- Budd-Chiari syndrome (BCS) involves blockage of the hepatic veins and is often linked to a condition that causes increased blood clotting.
- Systemic amyloidosis is a disorder where misfolded proteins accumulate in the body, causing organ damage, and it typically leads to bleeding issues rather than clotting.
- The case of a 40-year-old man illustrates how AL amyloidosis can lead to BCS, showing the importance of recognizing its varied and non-specific symptoms for accurate diagnosis.
Amyloid precursor protein as a fibrosis marker in infants with biliary atresia.
Pediatr Res
September 2024
Department of Respiratory and Infectious Medicine, Hannover Medical School, Hannover, Germany.
Background: Biliary atresia (BA) is a rare condition of unknown origin in newborns with jaundice. In BA bile ducts are non-functional, causing neonatal cholestasis and following liver fibrosis and failure.
Methods: This retrospective study included liver biopsies of 14 infants with BA aged [mean ± SD] 63 ± 23 days.
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