In the present study we aimed to investigate whether basal inhibin A and B levels in women with polycystic ovary syndrome (PCOS) would be used in diagnosis of the condition. Forty women with PCOS and 40 women with normal cycles (control group) were evaluated. There was no statistically significant difference in mean age and mean body mass index between the two groups (p > 0.05). Serum levels of inhibin A and B, follicle-stimulating hormone (FSH), luteinizing hormone and total testosterone, and total ovarian volume, were determined in the PCOS group and the control group on day 3. In the PCOS group, total follicle number was obtained by counting follicles of diameter > or =2 mm in both ovaries. Results were evaluated using Student's t test, Pearson correlation and regression tests. There was no significant difference in mean basal inhibin A or inhibin B levels between the two groups. Basal inhibin B levels showed a statistically significant negative correlation with basal FSH levels and a positive correlation with total follicle number in the PCOS group (p < 0.05 and p < 0.01, respectively). We conclude that basal inhibin A or B levels cannot be used in the diagnosis of PCOS.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/09513590500098125 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Basal and stimulated inhibin B in pubertal disorders.
J Clin Endocrinol Metab
January 2025
3Department of Metabolism, Digestion and Reproduction, Imperial College London.
Pubertal disorders in the form of delayed puberty (DP) or precocious puberty (PP) can cause considerable anxiety to both children and parents. Since the clinical and biochemical signatures of self-limiting and permanent conditions overlap considerably, it can be hard to determine whether to offer them reassurance or intervention. Researchers have thus long been searching for a robust test to indicate that the process of endogenous puberty is underway and is likely to proceed to completion.
View Article and Find Full Text PDFRole of Inhibin B, AMH, GnRHa Test and HCG Stimulation Test to Distinguish Isolated Hypogonadotropic Hypogonadism (IHH) from Constitutional Delay in Growth and Puberty (CDGP).
Indian J Endocrinol Metab
November 2023
Department of Endocrinology, M.K.C.G Medical College, Berhampur, Odisha, India.
Introduction: This study aimed to distinguish isolated hypogonadotropic hypogonadism (IHH) from constitutional delay in growth and puberty (CDGP) by various hormonal tests in both sexes.
Methods: Boys with testicular volume (TV) <4 ml (14-18 years) and girls with breast B stage (13-18 years) were enrolled in this study. A detailed history, clinical examination and hormonal analysis including basal luteinising hormone (LH), follicle-stimulating hormone (FSH), inhibin B, anti-Mullerian hormone (AMH), testosterone (boys), oestradiol (girls), triptorelin stimulation test and 3-day human chorionic gonadotropin (HCG) stimulation test (boys) were performed.
[Bushen Culuan Formula in treatment of infertility caused by polycystic ovary syndrome].
Zhongguo Zhong Yao Za Zhi
April 2024
Chinese Medical College, Tianjin University of Traditional Chinese Medicine Tianjin 301617, China.
Article Synopsis
- - This study investigates the effectiveness and safety of the Bushen Culuan Formula for treating infertility linked to polycystic ovary syndrome (PCOS) by using metabolomics to analyze the underlying mechanisms.
- - Ninety-four PCOS patients were divided into treatment and control groups; results showed the treatment group had significantly higher response and pregnancy rates, along with improved hormone levels and ovarian function.
- - Metabolomics analysis revealed 24 specific metabolites correlated with hormone levels, suggesting that the Bushen Culuan Formula may help regulate sex hormones through changes in lipid and amino acid metabolism.
Basal and FSH-stimulated Inhibin B in Precocious Puberty.
Indian Pediatr
August 2024
Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Objective: To evaluate the role of basal and follicle-stimulating hormone (FSH)-stimulated inhibin B in differentiating premature thelarche from gonadotropin-dependent precocious puberty (GDPP).
Methods: This was a prospective interventional study. Basal and FSH-stimulated inhibin B levels were estimated in girls presenting with thelarche < 8 years age (n = 10), healthy girls with normal pubertal development (pubertal control) (n = 8) and healthy prepubertal girls (prepubertal control) (n = 7).
Signaling Pathway Alterations Driven by BRCA1 and BRCA2 Germline Mutations are Sufficient to Initiate Breast Tumorigenesis by the PIK3CAH1047R Oncogene.
Cancer Res Commun
January 2024
Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
Unlabelled: Single-cell transcriptomics studies have begun to identify breast epithelial cell and stromal cell specific transcriptome differences between BRCA1/2 mutation carriers and non-carriers. We generated a single-cell transcriptome atlas of breast tissues from BRCA1, BRCA2 mutation carriers and compared this single-cell atlas of mutation carriers with our previously described single-cell breast atlas of healthy non-carriers. We observed that BRCA1 but not BRCA2 mutations altered the ratio between basal (basal-myoepithelial), luminal progenitor (luminal adaptive secretory precursor, LASP), and mature luminal (luminal hormone sensing) cells in breast tissues.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!