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Nanotechnology-Enhanced Pharmacotherapy for Intervertebral Disc Degeneration Treatment.
Int J Nanomedicine
January 2025
Department of Hand Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an Honghui Hospital North District, Xi'an, Shaanxi, 710000, People's Republic of China.
Intervertebral disc degeneration (IDD) is a primary contributor to chronic back pain and disability globally, with current therapeutic approaches often proving inadequate due to the complex nature of its pathophysiology. This review assesses the potential of nanoparticle-driven pharmacotherapies to address the intricate challenges presented by IDD. We initially analyze the primary mechanisms driving IDD, with particular emphasis on mitochondrial dysfunction, oxidative stress, and the inflammatory microenvironment, all of which play pivotal roles in disc degeneration.
View Article and Find Full Text PDFA stimuli-responsive drug delivery system based on konjac glucomannan, carboxymethyl chitosan and mesoporous polydopamine nanoparticles.
Int J Biol Macromol
December 2024
Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China. Electronic address:
A stimuli-responsive drug delivery system is developed for controlled delivery of curcumin (Cur) and chemo-photothermal therapy of breast cancer (BC). Cur is first loaded into mesoporous polydopamine nanoparticles (mPDA NPs) by π-π stacking, and then the Cur loaded mPDA NPs (mPDA NPs@Cur) are encapsulated in the hydrogels prepared through the crosslinking of oxidized konjac glucomannan (oxKGM) and carboxymethyl chitosan (CMCS). Owing to the pH-sensitivity of the hydrogels and the outstanding photothermal conversion capability of mPDA NPs, the release of Cur from the hydrogels can be greatly accelerated in acidic media upon near infrared (NIR) irradiation.
View Article and Find Full Text PDFStimuli-responsive hydrogels for bone tissue engineering.
Biomater Transl
September 2024
Department of Orthopaedics, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
The treatment of bone defects remains a great clinical challenge. With the development of science and technology, bone tissue engineering technology has emerged, which can mimic the structure and function of natural bone tissues and create solutions for repairing or replacing human bone tissues based on biocompatible materials, cells and bioactive factors. Hydrogels are favoured by researchers due to their high water content, degradability and good biocompatibility.
View Article and Find Full Text PDFMicrogels of N-Isopropylacrylamide Copolymerized with an Amphiphilic Acid for the Delivery of Doxorubicin.
Gels
December 2024
Faculty of Chemical Sciences and Engineering, Autonomous University of Baja California, University Boulevard No. 14418, Otay Mesa, Tijuana 22390, Mexico.
This study aims to design microgels that are thermo- and pH-sensitive for controlled doxorubicin (Dox) release in response to tumor microenvironment changes. N-isopropylacrylamide (NIPAAm) is widely used for thermoresponsive tumor-targeted drug delivery systems for the release of therapeutic payloads in response to temperature changes. Herein, a NIPAAm microgel (MP) that is responsive to temperature and pH was designed for the smart delivery of Dox.
View Article and Find Full Text PDFStimuli-Responsive DNA Nanomachines for Intracellular Targeted Electrochemiluminescence Imaging in Single Cells.
Angew Chem Int Ed Engl
December 2024
Fudan University, Department of Chemistry, Institute of Biomedical Sciences, Handan road, 200433, Shanghai, CHINA.
Electrochemiluminescence (ECL) microscopy has emerged as a powerful technique for single-cell imaging owing to its unparalleled background-free imaging advantages. However, controlled intracellular ECL imaging remains challenging. Here, we developed a stimuli-responsive self-assembled DNA nanomachine that enables the ECL imaging of intracellular target biomolecules in single cells.
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