Purpose: To compare the outcome of corneas obtained at the same hospital in which they were transplanted (group 1) to that of corneas obtained in the United States and grafted in Israel (group 2).
Methods: One hundred twenty-six patients undergoing corneal grafting in Israel during the years 1995 to 1998 were included in a retrospective, nonrandomized clinical trial. Group 1 included 31 procedures, and group 2 included 95. Data regarding preoperative condition, tissue characteristics, and postoperative outcome were collected from hospital charts. Statistically significant difference between groups was considered as P < 0.05.
Results: Follow-up time was 796 +/- 523 days for group 1 (mean +/- SD) and 815 +/- 510 days for group 2. Donor age and gender, recipient age and gender, graft size, and length of follow-up were similar. Time from preservation to transplantation was longer for group 2 (8.8 +/- 2.29 days) compared with in group 1 (3.13 +/- 2.38 days). Graft clarity was similar between groups 1 and 2 at 1 year (79% versus 71%) and at last follow-up visit (57% versus 62%). Visual acuity, intraocular pressure, and incidence of complications such as rejection (32% versus 38%), failure (35% versus 28%), secondary glaucoma (35% versus 43%), corneal ulcer (13% versus 6%), and regrafts (13% versus 7%) showed no difference between the groups.
Conclusions: Air transport of corneal tissue, including loss of time due to travel and handling, did not compromise corneal transplantation success rate.
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http://dx.doi.org/10.1097/01.ico.0000157419.11448.59 | DOI Listing |
J Clin Med
January 2025
Eye Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, 25123 Brescia, Italy.
: The aim of this study was to evaluate the effect of a surgical technique for managing post-penetrating keratoplasty (PK) ectasia complicated by late endothelial failure (LEF). : A single-center pilot case series was conducted regarding consecutive patients affected by post-PK ectasia with late graft failure. Using a microkeratome, a single donor cornea was dissected to prepare a two-piece graft, comprising a larger anterior lamella made up of anterior stroma and a smaller posterior lamella made up of posterior stroma, Descemet's membrane, and endothelium.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Cell Engineering Laboratory, La Paz University Hospital Health Research Institute, IdiPAZ, 28046 Madrid, Spain.
The World Health Organization estimates that approximately 285 million people suffer from visual impairments, around 5% of which are caused by corneal pathologies. Currently, the most common clinical treatment consists of a corneal transplant (keratoplasty) from a human donor. However, worldwide demand for donor corneas amply exceeds the available supply.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
NDDH, Royal Devon University Healthcare NHS Foundation Trust, Barnstaple EX31 4JB, UK.
Pseudoexfoliation syndrome (PXS) is an age-related fibrillopathy where fibrillar exfoliation material accumulates and deposits in ocular and extra-ocular tissue. Within the eye, this substance accumulates on the ocular surface and in the anterior segment of the eye, impacting ocular structures such as the conjunctiva, Tenon's capsule, sclera, cornea, iris, ciliary body, trabecular meshwork, and lens. This review aims to collate the current literature on how each anatomical part of the eye is affected by PXS, with a strong focus on molecular changes.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Key Laboratory of Biology and Medical Engineering, School of Biology and Engineering (School of Modern Industry for Health and Medicine), Guizhou Medical University, Guiyang 550001, China.
Corneal injury is prevalent in ophthalmology, with mild cases impacting vision and severe cases potentially resulting in permanent blindness. In clinical practice, standard treatments for corneal injury involve transplantation surgery combined with pharmacological therapy. However, surgical sutures exhibit several limitations, which can be overcome using tissue adhesives.
View Article and Find Full Text PDFCell Transplant
January 2025
Department of Nanotoxicology and Molecular Epidemiology, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
The eye represents a highly specialized organ, with its main function being to convert light signals into electrical impulses. Any damage or disease of the eye induces a local inflammatory reaction that could be harmful for the specialized ocular cells. Therefore, the eye developed several immunoregulatory mechanisms which protect the ocular structures against deleterious immune reactions.
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