AI Article Synopsis
- The study assessed chloroquine treatment failure and the genotype failure index in Burkina Faso across four sites.
- In three locations, the genotype failure index ranged from 1.7 to 3, highlighting a correlation between the Pfcrt T76 mutation and chloroquine resistance in the Plasmodium falciparum strain.
- One site showed a notably low genotype failure index of 1.1, suggesting variability in resistance patterns; overall, the Pfcrt T76 genotype index is a useful, though not infallible, measure for estimating chloroquine resistance.
Article Abstract
The prevalence of chloroquine (CQ) treatment failure and the genotype failure index was determined in four sentinel sites in Burkina Faso. In three sites, the genotype failure index varied between 1.7 and 3, a result confirming the relationship between the Plasmodium falciparum CQ resistance transporter (Pfcrt) T76 mutation and CQ resistance. In the remaining site, the genotype failure index was unusually low, 1.1, which was significantly different than that in the other sites (P < 0.00001). These findings are discussed. Often but not always, the prevalence of CQ resistance can be correctly estimated by the Pfcrt T76 genotype failure index.
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