We conducted a study in order to confirm the eligibility of fosfomycin trometamol as an alternative treatment to quinolones for urinary tract infections. Among 102 quinolone-resistant Enterobacteriaceae strains, resistance rates to first line-prescribed antibiotics were above 77%. The resistance rate to fosfomycin was 2%.
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Presence of qnr and aac(6́)-Ib-cr Genes among Quinolone Resistant Proteus species Isolates at Mymensingh, Bangladesh.
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Discovery of clinical isolation of drug-resistant with overexpression of OqxB efflux pump as the decisive drug resistance factor.
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Background emergence of multidrug-resistant (MDR) bacterial strains is a public health concern that threatens global and regional security. Efflux pump-overexpressing MDR strains from clinical isolates are the best subjects for studying the mechanisms of MDR caused by bacterial efflux pumps. A strain overexpressing the OqxB-only efflux pump was screened from a clinical strain library to explore reverse OqxB-mediated bacterial resistance strategies.
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