AI Article Synopsis
- Functionalized G(3) and G(4)-PAMAM dendrimers were synthesized and characterized using MALDI-TOF MS and NMR spectroscopy.
- Precipitation assays were conducted to evaluate the interaction of these dimannose-functionalized dendrimers with Cyanovirin-N, a protein that inhibits HIV by preventing virus-to-cell fusion.
- The study focuses on the potential of these dendrimers to enhance the effectiveness of HIV treatments through their binding properties.
Article Abstract
Manalpha1-2Man functionalized G(3) and G(4)-PAMAM dendrimers have been synthesized and characterized by MALDI-TOF MS and NMR spectroscopy. Precipitation assays to assess the binding of the dimannose-functionalized dendrimers to Cyanovirin-N, a HIV-inactivating protein that blocks virus-to-cell fusion through high mannose mediated interactions, are presented.
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| http://dx.doi.org/10.1039/b417789d | DOI Listing |
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