Background: Medial opening wedge high tibial osteotomy is gaining popularity as a treatment option for medial compartment degenerative disease in the young, active patient. One of the potential technical pitfalls of this procedure is inadvertent disruption of the lateral tibial cortex during distraction at the osteotomy site.
Purpose: (1) To investigate the effect of lateral cortex disruption on stability during medial opening wedge high tibial osteotomy and (2) to evaluate 3 different methods of repair of the disrupted lateral cortex.
Study Design: Controlled laboratory study.
Methods: A total of 50 validated replicate tibias were evaluated in a medial opening wedge high tibial osteotomy model. Specimens were divided into 5 groups: (1) control, or intact lateral cortex (n = 10); (2) disrupted lateral cortex (n = 10); (3) lateral cortex repaired with 1 staple (n = 10); (4) lateral cortex repaired with 2 staples (n = 10); and (5) lateral cortex repaired with a periarticular plate and screws (n = 10). Specimens were placed in compression and torsion under physiologic loads, and stiffness and micromotion were calculated.
Results: Disruption of the lateral cortex resulted in a 58% reduction in axial stiffness and a 68% reduction in torsional stiffness compared to control specimens (P < .05). Disruption of the lateral cortex also resulted in increased micromotion at the osteotomy site. All 3 methods of repair of the lateral cortex restored stiffness and micromotion values to those of the control group (P < .05).
Conclusions: Instability at the osteotomy site may contribute to the high rate of delayed union or nonunion associated with medial opening wedge high tibial osteotomy. Repair of the lateral tibial cortex by each of these techniques restored stability to the osteotomy site in this replicate tibia model and might be effective in clinical use. However, more studies are needed to further explore the relationship between lateral cortex disruption and patient outcomes in the clinical setting before definitive conclusions can be drawn.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1177/0363546505275488 | DOI Listing |
Front Aging Neurosci
January 2025
Department of Rehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Background: The perception of Subjective Visual Vertical (SVV) is crucial for postural orientation and significantly reflects an individual's postural control ability, relying on vestibular, visual, and somatic sensory inputs to assess the Earth's gravity line. The neural mechanisms and aging effects on SVV perception, however, remain unclear.
Objective: This study seeks to examine aging-related changes in SVV perception and uncover its neurological underpinnings through functional near-infrared spectroscopy (fNIRS).
CNS Neurosci Ther
January 2025
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Background: Alzheimer's disease (AD) is a debilitating neurodegenerative disorder that is difficult to predict and is typically diagnosed only after symptoms manifest. Recently, CD4 T cell-derived double-negative T (DNT) cells have shown strong immuno-regulatory properties in both in vitro and in vivo neuronal inflammation studies. However, the effectiveness of DNT cells in treating on AD are not yet fully understood.
View Article and Find Full Text PDFBMC Musculoskelet Disord
January 2025
Department of Rheumatology, the Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Tianhe District, Guangzhou, Guangdong Province, China.
Lower back pain comprises the majority of the disease burden of patients with ankylosing spondylitis (AS), while the alterations of the large-scale brain networks could be implicated in the neuropathophysiology of pain. The frontoparietal network (FPN) is known as a pain modulation hub, with key nodes dorsolateral prefrontal cortex (dlPFC) and ventrolateral prefrontal cortex (vlPFC) participating in the pain modulation and reappraisal process. In this study, we adopted the analytical approaches of independent component analysis (ICA) and seed-based correlation analysis (SCA) to examine the resting-state functional connectivity (rsFC) of the large-scale brain networks, notably FPN, between 82 AS patients and 61 healthy controls (HCs).
View Article and Find Full Text PDFExp Brain Res
January 2025
Dept. of Neurosurgery, Upstate Medical University, 750 E. Adams St, Syracuse, NY, 13210, USA.
Transcranial magnetic stimulation (TMS) has been used for many years to study the pathophysiology of amyotrophic lateral sclerosis (ALS). Based on single- or dual-pulse TMS and EMG and/or single motor unit (MU) recordings, many groups have described a loss of central inhibition as an early marker of ALS dysfunction, reflecting a state of cortical 'hyperexcitability'. This conclusion is not without its detractors, however, leading us to reexamine this issue using 4-pulse TMS, shown previously to be more effective for testing central motor pathway functional integrity.
View Article and Find Full Text PDFAppetite
January 2025
Department of Life Science and the Zelman Neuroscience Center, Ben-Gurion University, Beer Sheba, Israel.
Purpose: Behavioral and neurobiological abnormalities in addiction and obesity have led to the theory of food addiction in obesity (FAOB) and brain-behavior association studies. Transcranial magnetic stimulation (TMS) studies and treats various brain disorders. Cortico-cortical paired associative stimulation TMS protocol, in which left lateral prefrontal cortex (LPFC) stimulation follows right LPFC stimulation, can reduce emotional reactivity to visual triggers and modulate prefrontal asymmetry in healthy adults.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!