Startle eyeblink modification was measured during a continuous performance test (CPT) with either clearly focused stimuli or visually degraded stimuli to measure the effects of early perceptual processing demands on startle modification. A startling noise was presented either 120, 240, or 1200 ms following target and nontarget CPT stimuli. In the degraded stimulus CPT, startle inhibition at 240 ms was greater following targets than nontargets and was as great during targets at 240 ms as at 120 ms, whereas in the clearly focused CPT, inhibition declined significantly from 120 to 240 ms. The results indicate that maximum prepulse inhibition is extended in time when the task involves discrimination of degraded visual stimuli and when early perceptual processing demands are high. At 1200 ms, targets and nontargets produced nondifferential inhibition during both CPTs, suggesting that modality-specific attention occurred equally for the two tasks.
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http://dx.doi.org/10.1111/j.1469-8986.2005.00296.x | DOI Listing |
Current neural network models of primate vision focus on replicating overall levels of behavioral accuracy, often neglecting perceptual decisions' rich, dynamic nature. Here, we introduce a novel computational framework to model the dynamics of human behavioral choices by learning to align the temporal dynamics of a recurrent neural network (RNN) to human reaction times (RTs). We describe an approximation that allows us to constrain the number of time steps an RNN takes to solve a task with human RTs.
View Article and Find Full Text PDFBMC Med Imaging
January 2025
Electronics and Communications, Arab Academy for Science, Heliopolis, Cairo, 2033, Egypt.
Invasive breast cancer diagnosis and treatment planning require an accurate assessment of human epidermal growth factor receptor 2 (HER2) expression levels. While immunohistochemical techniques (IHC) are the gold standard for HER2 evaluation, their implementation can be resource-intensive and costly. To reduce these obstacles and expedite the procedure, we present an efficient deep-learning model that generates high-quality IHC-stained images directly from Hematoxylin and Eosin (H&E) stained images.
View Article and Find Full Text PDFPhys Eng Sci Med
January 2025
Department of Electronics and Communication Engineering, Vishnu Institute of Technology, Bhimavaram, Andhra Pradesh, 534202, India.
Schizophrenia (SZ) is a chronic neuropsychiatric disorder characterized by disturbances in cognitive, perceptual, social, emotional, and behavioral functions. The conventional SZ diagnosis relies on subjective assessments of individuals by psychiatrists, which can result in bias, prolonged procedures, and potentially false diagnoses. This emphasizes the crucial need for early detection and treatment of SZ to provide timely support and minimize long-term impacts.
View Article and Find Full Text PDFCan J Exp Psychol
January 2025
Department of Psychology, University of Western Ontario.
Episodic future thinking is the ability to project the self forward in time to preexperience a potential future event. It has been hypothesized that two components enhance simulations of future events: personal likelihood and event familiarity. Personal likelihood varies depending on the dynamics of personal goals throughout an individual's lifetime.
View Article and Find Full Text PDFFront Aging Neurosci
December 2024
Department of Psychology, Game Design, and Physical Therapy, Movement and Rehabilitation Services, Northeastern University, Boston, MA, United States.
A growing literature suggests that declines in sensory/perceptual systems predate cognitive declines in aging, and furthermore, they are highly predictive for developing Alzheimer's disease and Alzheimer's related dementias (ADRD). While vision, hearing, olfaction, and vestibular function have each been shown to be related to ADRD, their causal relations to cognitive declines, how they interact with each other remains to be clarified. Currently, there is substantial debate whether sensory/perceptual systems that fail early in disease progression are causal in their contributions to cognitive load and/or social isolation or are simply coincident declines due to aging.
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