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Integrating Diagnostic Approaches in Infant Bacterial Meningitis Caused by a Non-K1 : A Case Report.
Antibiotics (Basel)
November 2024
Microbiology and Diagnostic Immunology Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Background: Infant meningitis, particularly caused by , remains a life-threatening condition, especially in premature and low-weight infants. Infections of the central nervous system can be fatal, necessitating prompt diagnosis and appropriate treatment. Acute infections caused by various pathogens, including , often present with similar clinical symptoms.
View Article and Find Full Text PDFMolecular and clinical insights into extended-spectrum β-lactamase genes of Klebsiella pneumoniae isolated from neonatal sepsis in Ethiopia.
BMC Infect Dis
December 2024
School of Medical Laboratory Sciences, Faculty of Health Sciences, Jimma University, Jimma, Oromia, Ethiopia.
Background: Klebsiella bacterial strains harboring Extended-Spectrum Beta-Lactamase (ESBL) enzymes are the primary culprits behind neonatal sepsis globally. These strains significantly impact clinical outcomes due to their multi-drug resistance patterns in local healthcare settings. In response to this spiraling threat, we studied the prevalence and clinical implications of ESBL-encoding genes in neonates hospitalized with confirmed sepsis.
View Article and Find Full Text PDFUtility of direct microorganism species identification and antimicrobial susceptibility tests in urine samples.
J Infect Chemother
December 2024
Clinical Laboratory, Saitama Medical University International Medical Center, Saitama, Japan; Department of Laboratory Medicine, Saitama Medical University International Medical Center, Saitama, Japan. Electronic address:
Introduction: Urinary tract infections (UTIs) are one of the most common bacterial infections and a major cause of sepsis. It is important to promptly diagnose and treat UTIs.
Method: We found that a Gram-staining score of ≥2+ could be substituted for a colony-forming unit value of ≥10,000/mL.
Two multidrug-resistant clones carrying extended spectrum beta-lactamases revealed in a single hospital department by whole genome sequencing.
Heliyon
December 2024
Central Research Institute of Epidemiology, Novogireevskaya str., 3a, 111123, Moscow, Russia.
bacteria is a component of normal intestinal microflora of humans and animals, but can also be found in hospital settings causing urinary tract infections and sepsis. The problem of treating such infections is complicated by multidrug-resistant isolates producing extended spectrum beta-lactamases (ESBL), and the number of ESBL-carrying strains has significantly increased recently. This study presents a detailed analysis of 12 multidrug-resistant isolates obtained from the wounds of different patients in one surgical department of a multidisciplinary hospital in Moscow, Russia, using the short- and long-read whole genome sequencing.
View Article and Find Full Text PDFCampylobacter fetus Adrenal Abscess.
Cureus
November 2024
Department of Microbiology and Infectious Diseases, Concord Repatriation General Hospital, Sydney, AUS.
A 69-year-old highly comorbid female patient presented to the emergency department with sepsis following a month of fevers, myalgias, and lethargy. Abdominal imaging revealed an adrenal abscess, an aspirate of which grew ). The patient was treated with meropenem and then azithromycin; however secondary infection of the abscess cavity with an extended-spectrum beta-lactamase (ESBL)-producing () and failure of source control led to an extended clinical course.
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