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Gene expression profiling reveals an inflammatory process in the anx/anx mutant mice. | LitMetric

Gene expression profiling reveals an inflammatory process in the anx/anx mutant mice.

Brain Res Mol Brain Res

Experimental Neurobiology and Physiopathology Laboratory, Inserm U433, University Claude Bernard Lyon1, 8 rue Guillaume Paradin, 69372 Lyon cedex 08, France.

Published: October 2005

Anorexia (anx) is a recessive mutation that causes lethal starvation in homozygous mice. Studies of anx/anx mice hypothalamus have shown abnormalities in the orexigenic (NPY/AGRP neurons) and the anorexigenic (POMC/CART neurons) pathways. By gene expression profiling using cDNA and oligonucleotide microarrays, we have shown that a surexpression of genes involved in inflammatory process occurred in anx mice hypothalamus. This inflammatory process could be the cause of the anorexia phenotype observed in these mice.

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http://dx.doi.org/10.1016/j.molbrainres.2005.06.003DOI Listing

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